Surgery Rotation 11 Flashcards
Gastric varices are often caused by what?
Splenic vein thrombosis
What should you be concerned about if you treat H. Pylori with triple therapy and pain does not improve?
Zollinger Ellison (gastrin-secreting tumor)
Test for Zollinger Ellison
Secretin stimulation test = gastrin levels remain high after administration of secretin
Tx of Zollinger Ellison
Surgical resection of tumor (most likely in pancreas even though ulcers are in duodenum)
What else should you be looking for with Zollinger Ellison
MEN1
- Pituitary tumors (prolactin or GH)
- Pancreatic endocrine tumors (Zollinger-Ellison syndrome, insulinomas, VIPomas, glucagonomas)
- Parathyroid adenomas
Diff in tx of pt with acute onset vs gradual onset hypovolemic hypernatremia
acute = D5W
Gradual = D5W 1/2NS (pt has adjusted to hypernatremia so you can’t correct too quickly)
What is SMA syndrome?
- When the 3rd part of the duodenum (transverse section) gets compressed between the SMA and aorta
- Due to decrease in aortomesenteric angle
- This blocks food from passing from duodenum to jejunum, causing intestinal obstruction
Tx of SMA syndrome
Restore weight and nutrition
How do diagnose pancreatitis
- Increased amylase + lipase
- CT
Tx of pancreatitis
- Mostly supportive
- NG suction if nauseous, NPO for bowel rest, IV hydration, observation
Common complications of pancreatitis
Psuedocysts (no cells), hemorrhage, abscess, ARDS
What is Courvoisier’s sign
Large, nontender GB, itching and jaundice
Indicative of pancreatic cancer at head of pancreas
What is Trousseau’s sign associated with pancreatic cancer
Migratory thrombophlebitis
Diagnosis of pancreatic cancer?
Endoscopic US and FNA biopsy
When is a pancreatic tumor deemed “resectable”
No mets outside abd, no extension into SMA or portal vein, no liver mets, no peritoneal mets
What is the presentation associated with insulinoma
Whipple’s triad:
- Sxs (sweat, tremor, hunger, seizures)
- BGL < 45
- Sx resolve with glucose administration
What labs indicated real insulinoma vs. exogenous insulin administration
Labs: elevated insulin, C-peptide, and pro-insulin
Presentation of glucagonoma
Hyperglycemia, diarrhea, weight loss
Characteristic rash = necrolytic migratory erythema
Presentation of somatostatinoma
Malabsorption, steatorrhea
Commonly malignant
Presentation of VIPoma
WDHA
Watery diarrhea, hypokalemia, achlorhydia
Tx of VIPoma
Octreotide
Best first test if presumed gallbladder problem
US
Diagnose: RUQ pain, high bilirubin, high alkaline phosphotase
Thinking obstruction
Choledocholithiasis
Tx of choledocholithiasis
Chole +/- ERCP to remove stone
Diagnose: RUQ pain, fever, jaundice, decreased BP, AMS
Ascending cholangitis
Tx of ascending cholangitis
Abx
Remove stone with ERCP
Cause of hepatitis with ALT > AST (with both of them really high)
Viral hepatitis
Cause of hepatitis with AST = 2x ALT
Alcoholic hepatitis
Cause of hepatitis with AST and ALT high s/o hemorrhage, surgery, or sepsis
Shock liver: Hypotension = liver injury
Medical management of cirrhosis and portal HTN
Somatostatins for vasoconstriction to decrease portal pressure
Beta blockers to decrease portal pressure
What is downside to TIPS
Worsens encephalopathy because it bypasses clearance of pneumonia
Tx of hepatic encephalopathy
Lactulose (will poop it out)
Main risk factors for hepatocellular carcinom
Chronic HepB carrier > HepC
Cirrhosis
Tumor marker associated with hepatocellular carcinoma
AFP
Diagnose: women on OCP, palpable abd mass or spontaneous rupture, leading to hemorrhagic shock
Hepatic adenoma (tumors are fed by estrogen, which is why OCP is a risk factor)
Tx of hepatic adenoma
Stop OCP
Surgery usually not needed
2nd most common benign liver tumor
Focal nodular hyperplasia
Less likely to rupture
Most common cause of liver bacterial abscess
E. Coli, Bacterioides, Enterococcus
Tx of bacterial liver absces
Drainage + IV abx
Tx of amoebic abscess (Entamoeba histolytica - anchovy paste)
DO NOT drain
Tx with Metronidazole
Diagnose: Pt from south america with RUQ pain and lots of liver cysts
Hydatid cysts from Ecchinococcus - transmitted via dog feces
Lab findings in Ecchinococcus
Eosinophilia, + Casoni skin test
Tx of Echinococcus liver cyts
Surgery + Albendazole
Be careful of cyst rupture and spread