Internal Med 8 Flashcards
How do you determine if there is a coexisting metabolic disorder on top of pre-existing anion gap metabolic acidosis
• Determine the difference between calculated anion gap (Na – Cl – HCO3) and normal anion gap (12)
o This is how many extra H+ ions there are
o So you add this number to the measured bicarb to get “corrected” bicarb
o If corrected bicarb is greater than normal bicarb (24), you have a coexisting metabolic alkalosis
o If corrected bicarb is less than normal bicarb (24), you have a coexisting metabolic acidosis
o Example: Na = 140, Cl = 100, Bicarb = 10
♣ Anion gap = 30
♣ Difference between calculated anion gap and normal = 30 – 12 = 18
♣ Add 18 to bicarb to get “corrected” = 10 + 18 = 28
♣ Corrected bicarb is > normal bicarb of 24, so there is a coexisting metabolic alkalosis on top of this metabolic acidosis
Alternative tx of Syphilis if pt is allergic to Penicillin
Doxycycline
What is Whipple disease
♣ Infection with Tropheryma whipplei
♣ Symptoms: Weight loss, lymphadenopathy, hyperpigmentation, cardiac symptoms, arthralgias, neurologic symptoms
♣ Histology: Periodic acid Schiff, PAS (+) foamy macrophages in intestinal lamina propria
What would you expect to see on blood gas of a pt with asthma exacerbation
Respiratory alkalosis due to hyperventilation leading to decreased PaCO2
What would you expect to see in respiratory collapse of a pt with asthma exacerbtion who is unable to meet demands of increased respiratory drive
You will see a normal pH and PaCO2
Inability to maintain adequate ventilation caused by respiratory muscle fatigue or severe air trapping
What abx are used against Anaerobes (think of each category discussed by Jacob)
- Amox/Clav
- Amp/Sul
- Pip/Taxo
- Metronidazole
- Clindamycin
What abx are used against resistant GNR/Pseudomonas
- Pip/Tazo
- Cefepime
- Imipenem
- Meropenem
What abx are used against resistant GPC (MRSA)
- Vancomycin
- Linezolid
- Daptomycin
- TMP/SMX
- Doxy
- Clindamycin
What abd are used against atypicals
- Azithromycin
- Doxy
What is empiric tx of endocarditis
Vancomycin
- It will treat against main culprits: staph, strep, and enterococcus
What drug do you use for Vancomycin-resistant enterococci
Daptomycin
Describe what absorption of D-xylose / urinary excretion indicates
Can be used to assess for Celiac disease
o D-xylose is a monosaccharide that is aborobed in the small intestine without degradation by pancreatic or brush border enzymes
o Patients with small intestinal mucosal disease will have impaired absorption of D-xylose, and thus decreased urinary excretion of D-xylose
o Patients with malabsorption due to enzyme deficiencies (e.g. pancreatitis), will have normal absorption of D-xylose
What is contraction alkalosis?
o Although excess alkali are filtered in the glomerulus, they are also reabsorbed as a result of an activated RAAS
o Hypovolemia triggers RAAS in an attempt to conserve sodium and water
o Aldosteron functions to retain water at the expense of excreting both potassium and acid in the urine, despite total body acid depletion (contraction alkalosis)
How does Lithium cause nephrogenic DI
Lithium antagonizes the action of ADH in the collecting tubules, which means that aquaporins don’t get put into the collecting duct
How do you treat nephrogenic DI secondary to Lithium
Amiloride
• Lithium enters the convoluted tubule via the ENac channel, so inhibiting this channel will inhibit lithium entering, so Lithium can no longer antagonize the effect of ADH
What will you see in the setting of abrupt withdrawal of exogenous steroids in:
- Cortisol
- ACTH
- Aldosterone
This is tertiary adrenal insufficiency (problem of the hypothalamus)
- Low cortisol
- *Low ACTH
- Normal Aldo (controlled by RAAS)
Describe cause of common variable immunodeficiency (CVID)
o Defect in B-cell differentiation
♣ B cell count is normal
♣ Plasma cells and all immunoglobulins are decreased
Manifestations of CVID
♣ Recurrent respiratory (e.g. pneumonia, sinusitis, otitis) and GI (e.g. Salmonella, Campylobacter) infections
♣ Autoimmune disease (e.g. RA, thyroid disease)
♣ Chronic lung disease (e.g. bronchiectasis)
♣ GI disorders (e.g. chronic diarrhea, IBD-like conditions)