Structure & function of skeletal MUSCLES: Flashcards
What are myofibrils made from?
= fused cells that share a nuclei
= and cytoplasm, sarcoplasm
= there is a high number of mitochomdria
What are muscle fibres made from?
= millions of myofribrils
= made from:
=myosin
= actin
= forms a sacromere
What are myosin?
= thicker
What are actin?
= thinner
What is the sliding filament theory?
= when an action potential reaches a muscle, stimulates a response
= ca2+ ions enter and cause the protein, tropomyosin, that blocks the binding sites for the myosin head, of the actin, to move and uncover the active sites
= whilst ADP is attached to the myosin head, it can bind to the binding site ofthe actin to form a cross bridge
What does the cross bridge do?
= angle created in the cross bridge, creates tension, and as a result the actin filament is pulled and slides along the myosin
= the ADP molecule is released
= a new atp molecule binds to the myosin head and this energy causes the head to change shape slighly, and detaches from actin
What is found within the sarcoplasm?
= enzyme ATPase activated by calcium ions, hydrolyses ATP into ADP, onto the myson head, releases enough energy for mysoin head to return to original position
= entire process repeats, whilst calcium ions remain high,
What is ATP needed for?
= active muslces means a requires a high concentration of ATP
= when aerobic respiration cannot create enough ATP, to meet the demand, anaerobic respiration
= phosphocreatine, which isstored in muscles, assists by providing, phosphate to regenerate ATP from ADP
What is A band?
= total length of myosin, darker, there is also actin
What is a H zone? =
= where there is myosin early
What is the I band?
= where there is only actin, there is no overlap with myosin
What is the m line?
= middle point of the myosin
What is the z line?
= determines paremeters of 1 sarcomere- actin filaments
What happens to these bands when contraction happens?
= myosin attaches to the actin and slides the actin filaments closer to the middle,
= the actin are closer together, so I band becomes smaller
= H zone decreases,
= A band is constant
What are slow ti