step 3 4 Flashcards
Hypomagnesium differential
medication side effect (Diuretics, gentamicin, amphotericin, cisplatin), alcohol withdrawal, pancreatitis, parathyroid surgery
metabolic alkalosis differential
Primary: contraction alkalosis, cushing/conn syndromes, hypokalemia, milk-alkali syndrome, vomiting CLEVER PD C – contraction (dehydration) L – liquorice (diuretic), laxative abuse E – endocrine (Conn’s, Cushing’s) V – vomiting, GI loss (villous adenoma) E – excess alkali (antacids) R – renal (Bartter’s), severe K depletion P – post hypercapnia D – diuretics
hypokalemia metabolic alkalosis pathophys
potassium ions shift out to correct hypokalemia, which causes hydrogen ions to shift into the cell
episodic HTN think
pheochromocytoma
screening intervention that has the biggest effect on mortality
mammography
ER, PR postive breast cancer needs…
tamoxifen
when you need adjuvant chemo for breast cancer
positive axillary nodes or tumor is greater than 1 cm in size
patient is still menstruating
tamoxifen SEs
DVT
Hot flashes
Endometrial cancer
aromatase inhibitors mechanism-side effects
estrogen antagonist, osteoporosis
use of trastuzumab in breast cancer
HER-2/NEU positive metastatic disease
screening for single family member with colon cancer
at age 40 or 10 years earlier than age at which family member contracted cancer
screening for HNPCC, three family members, two generations, one premature
colonoscopy at age 25, then every 1-2 years
screening for FAP, Gardner’s syndrome, Peutz-Jeghers, Turcot’s syndrome
screening sigmoidoscopy at age 12, then every 1-2 years
lung cancer screening indication
30 pack year plus + age 55-75 + has not quite in past 15 years
contraindications to lung cancer resection
bilateral disease mets malignant pleural effusion involvement of aorta, vena cava, heart lesions within 1-2 cm of carina
cervical cancer screening
21-29, q3 years until 29, then pap + HPV (cotesting) q5 years until 65
pap smear results management
abnormal pap with low-grade or high grade dysplasia → colposcopy and biopsy
pap with atypical squamous cells of undetermined significance → HPV testing
HPV-positive pap → colposcopy
official recommendation for PSA
don’t offer, but if asked and patient is under 75, PSA + DRE
prostate cancer management
if localized – surgery + external radiation or implanted radioactive pellets
if metastatic – hormonal, not chemo, andogen blockade with flutamide and leuprolide or goserelin
management of cord compression in prostate cancer patient
flutamide