Spore Forming Bacilli Flashcards
Spore-Forming Bacilli
Bacillus anthracis
Clostridium botulinum
Clostridium perfringens
Clostridium tetani
Bacillus anthracis Diseases
Spore-Forming Bacilli
- Skin Anthrax/Skin Cutaneous Infection: Non-pus Lesions called escars leave a ring of small blisters that surround a dark center
- Pulmonary Anthrax/ Wool-sorter’s Disease/Inhalation Anthrax
- Typhoidal Anthrax/ Ingestion Anthrax
Bacillus anthracis Characteristics
Spore-Forming Bacilli
- Rod Shaped
- Endospore
- Gram-Positive: cell wall is thick; purple when stained; killed by penicillin
- Obligate Aerobic: microorganisms that can only live in the presence of oxygen, because they need oxygen to metabolize sugars
- Single or in chains
- Non-motile
Bacillus anthracis Virulence
Spore-Forming Bacilli
- Endospore
- Capsule (resists phagocytosis)
- Exotoxin
Bacillus anthracis Portals of Entry and Exit
Spore-Forming Bacilli
- Broken Skin: Direct contact with infected animal
- Respiratory Tract: Inhalation of pneumonic form
- GI Tract: Ingestion of contaminated meat
Bacillus anthracis Modes of Transmission
Spore-Forming Bacilli
- Direct: Directly handling infected animal
- Indirect: Inhalation
- Indirect: Ingestion of contaminated meat
Clostridium botulinum Diseases
Spore-Forming Bacilli
- Food-borne Botulism: flaccid paralysis, cardiac & respiratory failure, nausea, double or blurred vision
- Infant Botulism
- Wound Botulism: wounds are infected with spores
Clostridium botulinum Characteristics
Spore-Forming Bacilli
- Rod Shaped
- Endospore
- Gram-Positive: cell wall is thick; purple when stained; killed by penicillin
- Obligate Anaerobe: microbes that can only survive in an environment devoid of oxygen
Clostridium botulinum Virulence
Spore-Forming Bacilli
- Endospore
- Neurotoxin (causes Flaccid Paralysis: weakness of muscles to non-movement)
Clostridium botulinum Portals of Entry and Exit
Spore-Forming Bacilli
- Broken Skin: spores enter wounds
- GI Tract: Ingestion of contaminated meat/food
Clostridium botulinum Modes of Transmission
Spore-Forming Bacilli
- Indirect: Ingestion of contaminated meat
- Indirect: Wound contamination
Clostridium perfringens Diseases
Spore-Forming Bacilli
-
Gas Gangrene/Myonecrosis: Bacteria gather in an injury or surgical wound that has no blood supply.
The bacterial infection produces toxins that release gas and cause tissue death (antemortem) - Tissue Gas: Postmortem form of tissue gas; can spread through instruments
- Food Poisoning
Clostridium perfringens Characteristics
Spore-Forming Bacilli
- Rod Shaped
- Endospore
- Gram-Positive: cell wall is thick; purple when stained; killed by penicillin
- Obligate Anaerobe: microbes that can only survive in an environment devoid of oxygen
- Saprophyte: organisms that survive on dead or decaying organic matter
Clostridium perfringens Virulence
Spore-Forming Bacilli
- Endospore
- Enzymes: Hyaluronidae allows bacteria into the body’s connective tissues
Clostridium perfringens Portals of Entry and Exit
Spore-Forming Bacilli
- Indirect: Fomite contamination
- Indirect: Ingestion of contaminated meat/food