Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NAPLEX review 2024 RXPrep Book > Special Populations: Transplant > Flashcards

Special Populations: Transplant Flashcards

1
Q

Universal donor blood type

A

Type O

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Universal received blood type

A

Type AB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Allograft

A

transplant of an organ or tissue from one individual to another

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Isograft

A

transplant from a genetically identical donor = identical twins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Autograph

A

transplant from same patient, from one site to another

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Commonly used induction immunosuppression

A

Basiliximab (Simulect)

IL-2 receptor antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Patients at high risk of rejection that dont get Simulect could get…..

A

Atgam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Maintenance of immunosuppression

A
  1. Calcineurin inhibitor, CNI (Tacro first line)
  2. Antiproliferative (Mycophenolate or azathioprine, Myco 1st line)
  3. with or without steroids, usually prednisone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CNI medicaitons

A

Cyclosporine
Tacrolimus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cyclosporine boxed warnings

A

Nephrotoxicity
inc risk of lymphoma
inc risk of infection
inc BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Can you use modified and non-modified cyclosporine interchangeably?

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cyclosporine Side effects

A

inc BP
nephropathy
hyperkalemia
hypomagnesemia
hirsutism
gingival hyperplasia
edema
inc BG
neurotoxicity
QT prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cyclosporine monitoring

A

trough lvls
serum electrolytes
renal function
BP
BG
lipid profile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tacrolimus boxed warning

A

inc susceptibility to infection
possible development of lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tacrolimus side effects

A

inc BP
nephrotoxicity
alopecia
QT prolongation
Hyperlipidemia
hyperkalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tacrolimus monitoring

A

trough lvls
serum electrolytes
renal function
LFTs
BP
BG
lipid profile

17
Q

Mycophenolate Mofetil (CellCept) & Mycophenolic Acid (Myfortic) Boxed warning

A

inc risk of infection
lymphoma and skin malignancies
inc risk of congenital malformations and spontaneous abortions

18
Q

Mycophenolate side effects

A

Diarrhea
GI upset

Myfortic is enteric coated = decreased diarrhea

19
Q

Azathioprine Boxed warning

A

inc risk of malignancy
hematologic toxicities
mutagenic potential

20
Q

Everoliumus (Zortress) MOA

A

mTOR kinase inhibitors = inhibit T-lymphocyte activation/proliferations. can be synergistic with CNIs

21
Q

Everolimus Boxed warnings

A

inc risk of infection and cancers
reduced dose when used with cyclosporine

22
Q

Everolimus warnings

A

Hyperlipidemia
impaired wound healing

23
Q

Everolimus side effects

A

Peripheral edema
inc BP
N/V/D
dont use within 30 days of transplant

24
Q

Everolimus monitoring

A

trough lvls
renal functions
LFTs

25
Q

Sirolimus warnings

A

impaired wound healing
hyperlipidemia
angioedema

26
Q

Sirolimus side effects

A

irreversible pneumonitis/bronchitis/cough = d/c if develops
inc BG
peripheral edema

27
Q

Prednisone short term side effects

A

fluid retention
stomach upset
emotional instability
insomnia
inc appetite
weight gain
acute rise in BG and BP w/ high doses

28
Q

Prednisone long term side effects

A

adrenal suppression/Cushing’s syndrome
impaired wound healing
inc BP
Diabetes
acne
osteoporosis
impaired growth in children

29
Q

Belatacept (Nulojix) boxed warnings

A

inc risk of post-transplant lymphoproliferative disorder (PTLD)
use in EBV seropositive patients only

30
Q

Belatacept (Nulojix) warnings

A

treat latent TB prior to use

31
Q

Azathioprine with Xanthine oxidase inhibitors

A

CI w/ febuxostat

if using w/ allopurinol, reduce azathioprine dose by 75%

32
Q

How to treat acute cellular rejection

A

give high-dose steroids and inc lvls of maintenance immunosuppression

ATGAM givne for steroid resistant or more aggressive ACR.
can use alemtuzumab off-label

33
Q

Antibody-mediated rejection (AMR) treated with….

A

plasmapheresis and admin of IVIG and steroids, followed by dose of Rituxmab

NAPLEX review 2024 RXPrep Book (78 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions