Human Immunodeficiency Virus Flashcards
AIDS diagnosed when…
CD4 count > 200 or patient has an AIDs-defining condition
HIV transmission
Direct contact with blood, semen, vaginal or rectal secretions or ingestion of breast milk.
High risk indicators for HIV are….
Sharing drug injection equipment
High risk sexual behavior: MSM, multiple partners, hx of STIs
Hx of hepatitis or TB infection
HIV antibody testing
can be detected in people 4-12 weeks after getting disease, but can take up to 6 months
OraQuick Test
OTC test that tells you instantly
have to get follow up test with HCP
should be used > 3 months after exposure, if sooner can be false negative
Which drug is CCR5 antagonist
Maraviroc
CCR5 co-receptor on CD4 cell that HIV stages to
Which drug is attachment inhibitor
fostemsavir
Which drug is a post-attachment inhibitor
ibalizumab-uiyk
Which drug is a fusion inhibitor
enfuvirtide
Which drugs are nucleoside reverse transcriptase inhibitors (NRTIs)
emtricitabine
tenofovir
Which drugs are non-nucleoside reverse transcriptase inhibitors (NNRTIs)
efavirenz
rilpivirine
Which drugs are Integrase strand Transfer inhibitors (INSTIs)
Bictegravir
Dolutegravir
Raltegravir
Which drugs are protease inhibitors (PIs)
Atazanavir
Darunavir
Which allele do you test for if considering using abacavir?
HLA-B*5701
Which assay do you perform if considering using maraviroc?
Tropism assay
Preferred initial ART treatment
Biktarvy, Triumeq, Dovato = 1 single pill
Tivicay + Descovy/Truvada = 2 pills once daily
Triumeq should not be taken if test for….
HLA-B*5701
contains abacavir
Which HIV meds should not be used if CrCl < 30
Biktarvy, Triumeq, Dovato, Truvada and Descovy
Which HIV medication is given IV to mother to protect baby?
Zidovudine
in patients with unknown HIV RNA lvl or > 1,000
list of NRTIs
Abacavir
Emtricitabine
Lamivudine
TDF
TAF
Zidovudine
Warnings for All NRTIs
lactic acidosis and hepatomegaly with fatty liver
all can cause N/D/HA inc LFTs