Somatoestatina Flashcards

1
Q

¿Por cuantos a.a. esta conformada la somatostatina?

A

14 a.a. en forma de anillo que se une por un puente

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2
Q

¿Donde se produce la somatostatina?

A

c. δ del páncreas
Hipotálamo
Algunas zonas SNC

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3
Q

Vida media de somatoestatina

A

3 min

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4
Q

Funciones de somatostatina

A

Inh / reg hormonas (GH)
Inh motilidad y secreción S. digestivo
Aumenta a.a. y a. grasos

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5
Q

Somatostatinoma

A

Tum secretante de somatostatina
Deriva de c.δ

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6
Q

¿Con que se asocia el somatostatinoma?

A

Diabetes mellitus
Esteatorrea
Colelitiasis
Hipoclorhidria

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7
Q

Feedback positivo de somatostatina

A

Comer
↑ glicemia
↑ a.a.
↑ a. grasos
↑ hormonas gastrointestinales

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8
Q

¿Qué somatoestatina es más activa para inh la secreción de insulina?

A

Somatostatina 28

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9
Q

¿Qué hormonas inh la somatostatina?

A

GH
Insulina
Glucagon
Polipéptido panc.

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10
Q

¿Porqué se libera la somatostatina?

A

Ingesta de carbs y a.a.

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11
Q

¿Somatostatina inh glucagon o insulina?

A

Inh ambas

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