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SEM-III Fisiología General > Glucagon > Flashcards

Glucagon Flashcards

1
Q

Vida media del glucagon

A

6 min

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2
Q

¿Por cuántos a.a. esta conformado el glucagon?

A

29 a.a.

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3
Q

Regulación de glucagon

A

↑Glucemia inh síntesis
Hipoglucemia estimula síntesis

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4
Q

Función principal del glucagon

A

Sacar glucosa de las c. para aumentar la glucemia

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5
Q

Receptor de glucagon

A

Receptor aso prot Gs
Activa adenilato ciclasa en hepatocitos
↑AMPc

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6
Q

Acciones metabólicas de glucagon en HÍGADO

A

↑Glucogenolisis
↓Glucogenogénesis
↑Gluconeogénesis
↑Glucemia
↑Urea, creatinina y á. úrico

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7
Q

Acciones metabólicas de glucagon en TEJIDO ADIPOSO

A

↑Lipólisis
↓Síntesis á. grasos y triacilgliceroles

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8
Q

Las acciones del glucagon son contrarias a las acciones de…

A

La insulina

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9
Q

Hormona hipoglucemiante

A

Insulina

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10
Q

Hormonas hiperglucemientes

A

Glucagon
Adrenalina
Glucocorticoides
GH

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11
Q

Hipersecreción de glucagon

A

Efecto de Somogyi
Hiperglucemia
Glucagonomas (tum)

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12
Q

Límite de glucogeno muscular

A

2-3%

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13
Q

En periodos donde la glucemia y secreción de insulina disminuye, el glucogeno…

A

Glucogeno hepático se transforma en glucosa y se libera en sangre gracias a la acción del glucagon

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14
Q

Hiposecreción glucagon

A

Hipoglucemia

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15
Q

Efecto de Somogyi

A

Hipoglucemia nocturna desencadena hiperglucemia rebote en primeras horas de la mañana por glucogenolisis

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16
Q

¿La somatoestatina inhibe glucagon?

A

Si

17
Q

Sx de Glucagonomas

A

↑Glucogeno
Diabetes mellitus leve
Eritema migratorio necrolítico
Anemia

18
Q

Feedback positivo glucagon

A

Fac. que estimulan secreción
- a.a.
- acetilcolina
- cortisol
- colecistocinina
- ejercicio
- estimulantes adrenérgicos β
- infecciones
- infecciones
- fac. suprafisiológicos
- teofilina

19
Q

Feedback negativo glucagon

A

Fac. inh secreción
- a. grasos libres
- á. aminobuitrico γ
- estimulantes adrenérgicos α
- cetonas
- glucosa
- somatostatina
- secretina
- insulina
- fenilhidatoina

SEM-III Fisiología General (40 decks)

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