SODIUM VALPROATE

Question 1

WHAT IS SODIUM VALPROATE USED FOR?

Answer 1

epilepsy, migraines, mania

unlicensed: migraine prophylaxis

Question 2

dose in renal impairment?

Answer 2

reduce

Question 3

directions for IV administration of sodium valproate?

Answer 3

give over 3-5 minutes for injection

for infusion dilute with glucose or NaCl

Question 4

4 groups which shouldnt recieve sodium valproate?

Answer 4

childbearing age
acute porphyrias- mitochondrial disorders
personal or family history of hepatic dysfunction
systemic lupus

Question 5

why shouldnt sodium valproate be used in people iwth acute porphyrias?

Answer 5

mitochondrial disorders- higher rate of acute liver failure and liver related deaths

Question 6

adverse effects of sodium valproate to monitor?

Answer 6

liver toxicity: raised enzymes are usually transient but should be reassessed and mointored- for 6 months
blood and hepatic disorders
pancreatitis: seek medical attention if symptoms such as abdo pain, nausea, vomiting

Question 7

counselling points for sodium valproate?

Answer 7

symptoms of pancreatitis: abdo pain, N&V consult medical help
withdrawl must occur over at least 4 weeks

Question 8

side effects of sodium valproate?

Answer 8

abdominal pain, anaemia, alopecia, behavioural changes, agranulocytosis

Question 9

can you use in pregnancy?

Answer 9

no change to a different drug unless no alternative: sign a risk acknowledgement form
teratogenic: neurodevelopmental effects