Pharmacogenomics 2

Question 1

how many differences does each person have to the reference genome?

Answer 1

3-4 million

Question 2

importance of using pharmacogenomics for therapy?

Answer 2

ensure appropriate response- no ADEs

rule out toxicity

Question 3

carbamazepine pharmacogenomics?

Answer 3

severe skin reactions which can result in deaths- rare but prevalent in the chinese
shows importance of testing specific populations

Question 4

how can PG impact fluropyrimidines?

Answer 4

genetic variant for DPYD gene: lack of activity can result in fatal myelosuppression and toxicity