FUROSEMIDE

Question 1

WHAT IS FUROSEMIDE

Answer 1

a loop diuretic

inhibits reabsorption from the ascending limb of the loop of henle in the renal tubule

Question 2

monitoring

Answer 2

electrolytes

Question 3

adverse effects?

Answer 3

hypokalemia- dangerous in CVD and patients with caridac glycosides (dignoxin), in hepatic impairment this can precipitate encephalopathy

Question 4

contraindicated in?

Answer 4

renal failure due to nepthron toxic drugs
severe hypokalaemia and hyponatreamia
hepatic impairment- hypokalaemia may precipitate hepatic encephalopathy- use potassium sparing diuretic to prevent e.g. amiloride, spirinolactone
high doses or IV can cause tinnitus and deafness
anuria

Question 5

examples of potassium sparing diuretics

Answer 5

amiloride
spironolactone
eplerenone

Question 6

who should not receive these drugs?

Answer 6

CVD patients and those treated with cardiac glycosides
hepatic impairment- encephalopathy
enlarged prostate- urinary retention can occur
hepatorenal syndrome- may reduce diuretic effect and increase side effects

Question 7

why shouldnt it be used in hepatorenal syndrome

Answer 7

hypoproteinaemia may reduce the diuretic effect and increase risk of side effects