GENTAMYCIN

Question 1

how should gentamycin be admistered if theres renal impairment?

Answer 1

increase the intervals between doses
if severe then also decrease dose
mointor serum concentrations

Question 2

gentamycin effects if given in renal impairment at normal doses?

Answer 2

nephrotoxicity

ototoxicity

Question 3

children gentamycin IV dose/ make up?

Answer 3

glucose 5% or sodium chloride 0.9%; give over 20-30 minutes or 60 minutes if once daily regimen

Question 4

adults gentamycin iV dose/ makeup?

Answer 4

intermittently or via drip with glucose 5 or NaCl 0.9%. 50-100ml given over 20-30 minutes or 60 minutes if once daily

Question 5

who shouldnt recieve gentamycin?

Answer 5

people with auditory disorders

Question 6

what to monitor with gentamycin?

Answer 6

serum aminoglycoside concentations if renal impairment or elderly
if multiple daily doses- take bloods after 1 hour and just before next dose (peak and trough)
check concentration in children after 3-4 doses
auditory and vestibular function

Question 7

side effects of gentamycin

Answer 7

skin reactions
tinnitus
nausea and vomiting

Question 8

can you use gentamycin in pregnancy?

Answer 8

risk of auditory or vestibular nerve damage in the infant if used in 2nd or 3rd trimester
avoid unless essential
if given, must monitor serum levels

Question 9

what can happen if gentamycin is given to patients with mitochondrial disorders?

Answer 9

increasedrisk of deafness

Question 10

other types of aminoglycosies?

Answer 10

streptomycin, amikacin, tobramycin, neomycin

Question 11

TF: you dont need to worry about systemic absorption with topic administration of gentamycin?

Answer 11

false- absorption can occur

Question 12

gentamycin is C/I in?

Answer 12

myasthenia gravis- impairs neuromuscular transmission

dehydration: correct before injection

Question 13

how long should parenteral treatment be

Answer 13

try not to exceed 7 days