PARECOXIB

Question 1

what does parecoxib treat?

Answer 1

NSAID, cyclooxgenase 2 inhibitor for short term management of post-operative pain

Question 2

dose adjustment in hepatic impairment?

Answer 2

dose reduction to half the recommended dose in moderate impairment
maximum 40mg daily in hepatic impairment

Question 3

dose adjustment in renal impairment?

Answer 3

avoid if possible

lowest effective dose for shortest duration

Question 4

who shouldnt recieve this drug?

Answer 4

IBD patients

Question 5

monitoring of parecoxib in renal impairment ?

Answer 5

in renal impairment, monitor function, sodium and water retention

Question 6

CAUTIONS?

Answer 6

allergic disorders, cardiac impairment/ failre, dehydration (renal risj), elderly, GI disorders, hypertension, masks infection symptoms, oedema, CV risk factors

Question 7

contraindicated in?

Answer 7

active GI bleeding/ ulceration, cerebrovasular disease. after CABG surgery, IBD, ischemic heart sidease, HF, arterial disease

Question 8

side effects?

Answer 8

GI disorders, hypertension, electrolyte disturbance, hypotension, increased risk of infection, oedema, renal impairment, respiratory disorders, skin reactions, vomiting