PIOGLITAZONE

Question 1

how does pioglitazone work?

Answer 1

reduces insulin resistance

leading to a reduction in BG

Question 2

who cannot receive this drug?

Answer 2

HF or history
hepatic impairment
bladder cancer history or uninvestigated haematuria

Question 3

adverse effects of piioglitazone

Answer 3

fractures, infection risk, numbness, visual impairment, increased weight
bladder cancer, insomnia, macular oedema, liver dysfunction

Question 4

when should you discontinue

Answer 4

if jaundice occurs- hepatic function

Question 5

can it be given in pregnancy?

Answer 5

toxic in animal studies NO

Question 6

TF: pioglitazone can be used with insulin

Answer 6

FALSE- increased risk of HF

Question 7

cautions

Answer 7

insulin use, if they have an increased risk of bone fractures bladder cancer, heart failure

Question 8

predisposing factors to HF?

Answer 8

past MI

Question 9

why must pioglitazone be used in caution in the elderly

Answer 9

risk of BC increases as you age

Question 10

what should you do if little response to pioglitazone

Answer 10

discontinue after 3-6 months

Question 11

can you give in someone with BC risks?

Answer 11

yes if benefits outweigh the risks

Question 12

what should you monitor with pioglitazone therapy?

Answer 12

liver function before and periodically thereafter

Question 13

what signs of liver failure should patients look out for?

Answer 13

nausea, vomiting, abdo pain, fatigue, dark urine