SM_108b-108b: Depression and Bipolar Disorder I and II Flashcards

1
Q

Describe phenomenology of depression episodies

A

Depression episodes

  • Mood: depressed / sad / despondent / empty or blue, anxiety and irritability can be more prominent, lack of interest in pleasurable activities
  • Behavior: agitated or retarded, appetite and sleep disturbances
  • Thought: hopelessness / pessimisim / lack of self-esteem / guilt, somatic preoccupations, suicidality, and slowed mentation
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2
Q

Depressive symptoms include

  • ____
  • ____
  • ____
  • ____
  • ____
  • ____
  • ____
  • ____
A

Depressive symptoms include

  • Sleep disturbance
  • Interest reduced (anhedonia)
  • Guilt and worthlessness
  • Energy loss and fatigue
  • Concentration problems
  • Appetite problem
  • Psychomotr agitation or retardation
  • Suicidality

(SIGECAPS)

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3
Q

Describe DSM-5 criteria for major depressive episode

A

Major depressive episode DSM-5 criteria

  • Five or more of the following during the same 2 week period: depressed mood most of day nearly every day, markedly diminished interest or pleasure in activities, significant weight loss / gain or change in appetite, insomnia / hypersomnia, psychomotor agitation / retardation, fatigue / loss of energy, worthlessness / inappropriate guilt, diminished ability to think / concentrate / indecisiveness, recurrent thoughts of death or suicidal ideation
  • Symptoms cause significant distress or impairment in social, occupation, or other areas of functioning
  • Not attribuate to physiological effects of a substance or other medical condition
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4
Q

Depression may have ____ or ____ features

A

Depression may have melancholic or atypical features

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5
Q

Describe the phenomenology of mania

A

Mania

  • Mood: expansion / euphoric / grandiose / irritable / hospital, anxiety can be prominent
  • Behavior: decreased need for sleep, extravagance, agitation, impulsivity, high pursuit of pleasurable activities, pressured speech, loud
  • Cognition: racing thoughts, distractability, poor judgement, possible delusions, and hallucinations
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6
Q

Describe DSM-5 criteria for a manic episode

A

Manic episode DSM-5 criteria

  • ≥ 1 week of abnormally and persistently elevated, expansive, or irritable mood and persistently elevated activity / energy
  • During the period, 3 or more of: inflated self esteem / grandiosity, decreased need for sleep, more talkative, racing thoughts / flight of ideas, distractability, increase in goal-directed activity / psychomotor agitation, and excessive involvement in activities that have a high potential for painful consequences
  • Causes marked impairment in functioning
  • Not attributable to physiological effects of a substance or other medical condition
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7
Q

Describe DSM-5 criteria for a hypomanic episode

A

Hypomanic episode DSM-5 criteria

  • ≥ 4 days of abnormally or persistently elevated, expansive, or irritable mood and persistently increased activity or energy
  • During the period, 3 or more of: inflated self-esteem / grandiosity, decreased need for sleep, more talkative, flight of ideas / racing thoughts, distractability, increased goal directed activity / agitation, excessive involvement in activities that have a high potential for painful consequences
  • Unequivocal changes in functioning uncharacteristic of individual when not symptomatic
  • Change is observable by others
  • Not severe enough to cause marked impairment in social / occupational functioning or require hospitalization
  • Not attributable to physiological effects of a substance or other medical condition
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8
Q

Mixed features specifier applies when ____

A

Mixed features specifier applies when at least 3 subthreshold symptoms from the opposite pole are present during a mood episode

(can be used to describe depressive, manic, or hypomanic episodes)

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9
Q

Major depressive disorder with mixed features has ____ prognosis

A

Major depressive disorder with mixed features has poorer prognosis

(use mood stabilizers and some atypical antipsychotics)

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10
Q

Psychotic features specifier can be either ____ or ____

A

Psychotic features specifier can be either mood-congruent or mood-incongruent

(occur in major depressive, mania, or hypomania)

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11
Q

Depressive disorders include ____ and ____, while bipolar disorders include ____, ____, and ____

A

Depressive disorders include major depressive disorder and persistent depressive disorders, while bipolar disorders include bipolar I disorder, bipolar II disorder, and cyclothymic disorder

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12
Q

Describe DSM-5 criteria for major depressive disorder

A

Major depressive disorder DSM-5 criteria

  • One major depressive episode
  • Not better explained by other psychotic disorder
  • Never experienced a manic or hypomanic episode
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13
Q

Persistent depressive disorder requires never having had a ____ or ____

A

Persistent depressive disorder requires never having had a manic / hypomanic episode or cyclothymia

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14
Q

Bipolar I disorder requires a history of ____

A

Bipolar I disorder requires a history of manic episodes

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15
Q

Bipolar II disorder requires a history of ____

A

Bipolar II disorder requires a history of hypomanic episodes

(no manic episodes)

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16
Q

Cyclothymic disorder requires recurrent ____ and ____ lasting ≥ 2 years

A

Cyclothymic disorder requires recurrent mild depressive symptoms and hypomanias lasting ≥ 2 years

17
Q

Conditions commonly comorbid with major depressive disorder and bipolar disorder include ____, ____, and ____

A

Conditions commonly comorbid with major depressive disorder and bipolar disorder include alcohol / substance abuse, OCD / anxiety disorders, and other medical illnesses

18
Q

_____, defined as _____, describes the trend of recurrence of depression or bipolar disorder

A

Kindling, defined as increased risk of recurrence with each episode, describes the trend of recurrence of depression or bipolar disorder

19
Q

Depression with melancholic features involves ____ and ____

A

Depression with melancholic features involves loss of pleasure and lack of reactivity

20
Q

Depression with atypical features involves ____, ____, ____, ____, and ____

A

Depression with atypical features involves mood reactivity, significant weight gain / appetite increase, hypersomnia, leaden paralysis, longstanding pattern of interpersonal rejectio

21
Q

Neutrophic hypothesis of depression involves ____ and ____

A

Neutrophic hypothesis of depression involves

  • Atrophy, cellular, or damage with subsequent stressors in vulnerable individuals
  • Reduced neurogenesis (decreased BDNF)
22
Q

____ has been implicated in depression

A

Serotonin has been implicated in depression

23
Q

Biomarkers of recurrent major depressive disorder include ____, ____, ____, and ____

A

Biomarkers of recurrent major depressive disorder include

  • Decreased immune functioning: elevated TNFa, IL-6, CRP and mitochondrial dysfunction
  • Dysregulation of hypothalamic-pituity-thyroid axis: blunted TSH response to TRH
  • Volume reduction in basal ganglia, hippocampus, and frontal cortex
  • Decreased activity in left prefrontal cortex
24
Q

Elevated serum cortisol and CSF CRH, especially at night, indicates ____

A

Elevated serum cortisol and CSF CRH, especially at night, indicates major depressive disorder

(atypical disorder is hypocortisolemic)

25
Q

Describe bipolar pathogenesis

A

BIpolar pathogenesis

  • Norepinephrine
  • Altered glutamate transmission in hippocampus, thalamus, and other structures
  • Circadian dysregulation
  • Disruptions in cellular and membrane metabolism
  • Immunologic / inflammatory factors
  • Neuroanatomic reductions and neurocognitive impairment early in life
  • Regional differences in neurocircuitry activity: hypoactive PFC and overactive anterior cingulate and subcortical structures