Skin II Flashcards
most Staphylococci are ____-resistant because they secrete ____
most Staphylococci are penicillin-resistant because they secrete penicillinase (hydrolyze penicillin)
multidrug resistance of MRSA is mediated by an acquired chromosomal DNA segment, ____ which encodes a new ____
multidrug resistance is mediated by an acquired chromosomal DNA segment, mecA which encodes a new penicillin-binding protein 2A
list the risk factors for MRSA in the community
list the risk factors for MRSA in healthcare
describe CA-MRSA vs. HA-MRSA
___ is an important toxin used to differentiate between CA-MRSA and HA-MRSA
Pantin-Valentine leucocidin (PVL)
list the syndromes that affect the epidermis
- impetigo
- folliculitis
list the syndromes that affect the dermis
- ecthyma
- erysipelas
- furunculosis
- carbunculosis
list the syndromes that affect the hypodermis (sliding layer)
- necrotizing fasciitis
list the syndromes that affect the muscle
- myonecrosis
describe impetigo
- 3rd most common skin disease among children
-
risk factors:
- have an injury (cut, fracture, burn, scrape)
- contagious
- isolates of CA and HA-acquired MRSA in lesions of impetigo remains low
describe nonbullous impetigo
- the teichoic acid adhesions (fibronectin-binding proteins (FnBPs)) require the epithelial cell receptor component, fibronectin, for colonization
- these fibronectin receptors are unavailable on intact skin
in nonbullous impetigo, the ____ require the epithelial cell receptor component, ____, for colonization which is normally unavailable on ____ skin
in nonbullous impetigo, the teichoic acid adhesions (FnBPs) require the epithelial cell receptor component, fibronectin, for colonization which is normally unavailable on intact skin
describe bullous impetigo
- group II S. aureus
- cause: exfoliating toxin, a protease that degrades desmoglein-1, resulting in loss of adhesion of the superficial epidermis
- unlike nonbullous impetigo, the lesions of bullous impetigo occur on intact skin
bullous impetigo is caused by ____
bullous impetigo is caused by group II S. aureus