Multisystem V Flashcards
____ does NOT form pseudohyphae
Candida auris does NOT form pseudohyphae
the pathogenicity of Candida is facilitated by _____
the pathogenicity of Candida is facilitated by adherence to tissues
list 4 pathogenetic mechanisms of Candida spp.
- ability to exhibit yeast-hyphal dimorphism
- cell-surface hydrophobicity
- proteinase secretion
- phenotypic switching
___ is a key feature of C. auris that contributes to its antibiotic resistance
phenotypic switching is a key feature of C. auris that contributes to its antibiotic resistance
____ can cause serious bloodstream infections and is characterized by ____ and ___ that don’t improve after ____
Candida spp. can cause serious bloodstream infections and is characterized by fever and chills that don’t improve after antibiotic treatment
____ is used to diagnose Candida spp.
MALDI-TOF is used to diagnose Candida spp.
Candida spp. can be grown on ___ medium supplemented with ____
Candida spp. can be grown on CHROMagar medium supplemented with Pal’s medium
Coxsackiviruses are part of the ____ family of viruses
Coxsackieviruses are part of the Picornaviridae family of viruses
Coxsackieviruses are spread via ____ route of transmission
Coxsackieviruses are spread via fecal-oral route of transmission
Coxsackieviruses infect ___ in Peyer patches as well as ____ in the intestinal mucosa
Coxsackieviruses infect M cells & lymphocytes in Peyer patches as well as enterocytes in the intestinal mucosa
from the intestine, Coxsackieviruses can infect ____ cells
from the intestine, Coxsackieviruses can infect reticuloendothelial cells (LNs, spleen, liver)
the binding receptors for Coxsackieviruses are ___ and ____
the binding receptors for Coxsackieviruses are ICAM-1 and CD55
Coxsackievirus replicates in the ____ and produces a ____ that contains ____
Coxsackievirus replicates in the cytosol and produces a polyprotein that contains all the protein sequences
____ antibody can prevent initial infection of oropharynx and GI tract with Coxsackievirus
____ antibody prevents viremic spread of Coxsackievirus to target tissues and thus disease
secretory antibody can prevent initial infection of oropharynx and GI tract with Coxsackievirus
serum antibody prevents viremic spread of Coxsackievirus to target tissues and thus disease
describe the 2 diseases that Coxsackievirus A can cause
describe the 2 conditions caused by Coxsackie B virus
HHV4 is also known as ____
HHV4 is also known as EBV
list the 2 characteristic features of EBV infection
swollen lymph nodes in the neck
enlarged spleen
the replication of EBV occurs in epithelial cells of the ___ & ___ and establishes latent infections in ____
the replication of EBV occurs in epithelial cells of the oropharynx & parotid gland and establishes latent infections in lymphocytes
EBV in saliva initiates infection in ___ and ___ by binding ____
EBV in saliva initiates infection in oral epithelia and tonsillar B cells by binding CD21
EBV promotes growth of ____ and therefore ___ act to control the overgrowth of the ____
EBV promotes growth of B-cells and therefore CD8 T cells act to control the overgrowth of the B cells
summarize the pathogenesis of EBV
the triad of classical symptoms in EBV are:
lymphadenopathy
splenomegaly
exudative pharyngitis
HHV5 is also known as ____
HHV5 is also known as CMV
CMV is linked to ____ transplant failures
CMV is linked to kidney transplant failures
in severely immunocompromised patients, CMV can cause ___, ___ and ____
in severely immunocompromised patients, CMV can cause retinitis, colitis and esophagitis
____ is the most prevalent viral cause of congenital disease
CMV is the most prevalent viral cause of congenital disease
list clinical features of CMV in neonates
____ is the standard for diagnosing CMV
ELISA is the standard for diagnosing CMV
describe diagnosis of CMV
summarize the congenital infections
sensorineural hearing loss & chorioretinitis are seen in which congenital infection?
Rubella
microcephalus and chorioretinitis are seen in which congenital infection?
CMV
keratoconjunctivitis is seen in which congenital infection?
HSV
failure to thrive, severe thrush and calcification of basal ganglia are seen in which congenital infection?
HIV
skin lesions involving palms and soles, rhinorrhea, signs of osteochondritis and periostitis are seen in which congenital infection?
syphilis
