Skin

Question 1

Propionibacterium acnes infection produces

Answer 1

Lipases that break down sebum, releasing proinflammatory FA

Question 2

Psoriasis is due to

Answer 2

Excessive keratinocyte proliferation

Question 3

Psoriasis HLA

Answer 3

HLA-C

Question 4

Psoriasis histology

Answer 4

1. Acanthosis (epidermal hyperplasia)
2. Parakeratosis (hyperkeratosis with retention of keratinocyte nuclei in Stratum corneum)
3. PM in Startum corneum
4. Thinning of epidermis

Question 5

Auspitz sign

Answer 5

Bleeding when scale is picked off

Question 6

Lichen Planus 5 P’s

Answer 6

Pruritic Planar Polygonal Purple Papules

Question 7

Wickham striae

Answer 7

Reticular white lines on the surface of papules

Question 8

Lichen planus histology

Answer 8

Inflammation of the dermal-epidermal junction with saw-tooth appearance

Question 9

Lichen planus is associated with

Answer 9

Chronic Hep C

Question 10

Pemphigus vulgaris is

Answer 10

Autoimmune destruction of Desmosomes between keratinocytes

Question 11

Pemphigus vulgaris is due to

Answer 11

IgG antibody against desmoglein (Type 2 HS)

Question 12

Bullous pemphigoid is

Answer 12

Autoimmune destruction of Hemidesmosomes between basal cells and the underlying BM

Question 13

Bullus pemphigoid is due to

Answer 13

IgG antibody against BM collagen

Question 14

Dermatitis herpetiformis is

Answer 14

Autoimmune depostion of IgA at the tips of dermal papillae

Question 15

Dermatitis herpetiformis presents as

Answer 15

Pruritic vesicles and bullae that are grouped

Question 16

Dermatitis herpetiformis is associated with

Answer 16

Celiac disease

Question 17

Erythema multiforme is

Answer 17

HS reaction characterized by targetoid rash and bullae due to central epidermal necrosis surrounded by erythema

Question 18

Erythema multiforme is associeated with

Answer 18

1. HSV
2. Mycoplasma
3. Drugs:
   
   1. Penicillin
   2. Sulfonamides
4. SLE

Question 19

Erythema multiforme with oral mucosa/lip involvement with fever termed

Answer 19

Steven-Johnson Syndrome

Question 20

Seborrheic keratosis is

Answer 20

Benign squamous proliferation seen in elderly

Question 21

Seborrheic keratosis presents as

Answer 21

Raised, discolored plaques on the extremities or face

Coin-like, waxy, ‘stuck on’ appearance

Question 22

Seborrheic keratosis histology

Answer 22

Keratin pseudocysts

Question 23

Leser-Trélat sign is

Answer 23

sudden onset of multiple seborrheic keratoses that suggest underlying carcinoma of GI

Question 24

Actinic keratosis is a precursor lesion of

Answer 24

Squamous cell carcinoma

Question 25

Actinic keratosis presents as

Answer 25

Hyperkeratotic, scaly plaque

Question 26

Keratoacanthoma is

Answer 26

Well-differentiated squamous cell carcinoma that develops rapidly and regresses spontaneously

Question 27

Molluscum contagiosum due to

Answer 27

Poxvirus