Musculoskeletal

Question 1

Achondroplasia genetics

Answer 1

AD mution of FGFR3

Question 2

Osteogenesis imperfecta genetics

Answer 2

AD defect in collagen type 1 synthesis

Question 3

Paget disease of bone is due to

Answer 3

Imbalance between osteoclast and osteoblast

Question 4

3 stages of paget disease of bone

Answer 4

1. Osteoclastic
2. Mixed osteoblastic-osteoclastic
3. Osteoblastic

Question 5

Complications of Paget disease of bone

Answer 5

1. High-output cardiac failure
2. Osteosarcoma

Question 6

Osteomyelitis in sickle cell caused by

Answer 6

Salmonella

Question 7

Osteoid osteoma is

Answer 7

Benign tumor of osteoblasts

Question 8

Osteoid osteoma arise in

Answer 8

Cortex of long bone

Question 9

What age group does Osteoid osteoma occur in

Answer 9

Male <25

Question 10

Osteochondroma is

Answer 10

Tumor of bone with an overlying cartilage cap

Question 11

Osteosarcoma is

Answer 11

Malignant proliferation of osteoblasts

Question 12

Risk factors to Osteosarcoma

Answer 12

Familial retinoblastoma

Paget

Radiation

Question 13

Osteosarcoma arise in

Answer 13

The metaphysis of long bones

Distal femur or proximal tibia

Question 14

Codman triangle is

Answer 14

Sunburst appearance and lifting of periosteum in osteosarcoma

Question 15

Giant cell tumor arises in

Answer 15

Epiphysis of long bones

Distal femur or proximal tibia

Question 16

Giant cell tumor on x-ray

Answer 16

Soap-bubble appearance

Question 17

Ewing sarcoma translocation

Answer 17

t(11;22)

Question 18

Ewing sarcoma arises in

Answer 18

Diaphysis of long bones

Question 19

Joints affected by osteoarthritis

Answer 19

1. Hips
2. Lower lumbar spine
3. Knees
4. DIP
5. PIP

Question 20

Heberden nodes

Answer 20

Osteophyte formations in DIP due to osteoarthritis

Question 21

Bouchard nodes

Answer 21

Osteophyte formation in PIP due to osteoarthritis

Question 22

RA HLA is

Answer 22

HLA-DR4

Question 23

Pannus is

Answer 23

Inflamed granulation tissue in RA

Question 24

What is spared in RA

Answer 24

DIP

Question 25

Bamboo spine is seen in

Answer 25

Ankylosing spondyloarthritis

Question 26

Reiter sydrome is

Answer 26

Arthrits, Urethritis and conjunctivitis due to a GI or Chlamydia infection

Question 27

Dermatomyositis lab findings

Answer 27

1. Increased creatinine kinase
2. ANA and Anti-Jo-1 ab
3. Perimysial inflammation with perifascicular atrophy

Question 28

Myasthenia clinical

Answer 28

1. Muscle weakness that worsens with use and imporves with rest
2. Symptoms improve with anticholinesterase agents
3. Thymic hyperplasia or thymoma

Question 29

Lambert-Eaton syndrome is

Answer 29

Antibodies against presynaptic Ca

Question 30

Lamber-Eaton clinical

Answer 30

1. Proximal muscle weakness that improves with use (eyes are spared)
2. Anticholinesterase do not improve