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Inflammation, Inflammatory disorders, Wound healing Flashcards

1
Q

Activated Hageman factor activates

A

Coagulation and fibrinolytic system

Complements

Kinin system

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2
Q

Alternative pathway of activating complements involves

A

Microbial products directly activate complements

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3
Q

Arachidonic Acid released from phospholipid cell membrane by

A

Phospholipase A

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4
Q

C1 inhibitor deficiency results in

A

Hereditary angioedema

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5
Q

C5a is

A

Chemotactic for PMN

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6
Q

Chediak-Higashi clinical

A
  1. Increase risk of pyogenic infections
  2. Neutropenia (Due to intramedullary death of PMN)
  3. Giant granules in leukocytes
  4. Albinism
  5. peripheral neuropathy
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7
Q

Chediak-Higashi syndrome is

A

AR protein trafficking defect characterized by impaired phagolysosome formation

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8
Q

Classic pathway of activating complements involves

A

C1 binds IgG or IgM that is bound to antigen

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9
Q

CREST is

A
  • Calcinosis
  • Raynaud phenomenon
  • Esophageal dysmotility
  • Sclerodactyly
  • Telangiectasias of skin
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10
Q

CREST lab findings

A

Anti-centromere AB

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11
Q

Cu in wound healing

A

Cofactor for lysyl oxidase

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12
Q

DiGeorge clinical

A
  1. T-Cell deficiency due to lack of Thymus
  2. Hypocalcemia due to the lack of parathyroids
  3. Abdormalities of heart, great vessels and face
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13
Q

DiGeorge sydrome due to

A

22q11 microdeletion

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14
Q

DiGeorge sydrome is a developmental failure of

A

the 3rd and 4th pharyngeal pouches

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15
Q

Drug induced SLE lab findings

A

Antihistone AB

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16
Q

During adhesion, integrins are upregulated on leukocytes by

A

Cha and LTB4

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17
Q

E-selectin induced by

A

TNF and IL-1

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18
Q

Fibroblast growth factor role in wound healing

A

Important for angiogenesis

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19
Q

Granulomas are a collection of

A

Epithelioid histiocytes (macrophages with abundant pink cytoplasm) surrounded by giant cells and rim of lypmphocytes

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20
Q

H2O2 to HOCl

A

MPO

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21
Q

Hageman factor (Factor ΧΙΙ) is

A

inactive proinflammatory protein produced in liver

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22
Q

Hyper-IgM syndrome due to

A

Mutated CD40L inhibiting class switching

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23
Q

LAD clinical

A
  1. Delayed separation of umbilical cord
  2. Increase circulating PMN
  3. Recurrent bacterial infections that lack pus formation
24
Q

latelet-derived growth factor role in wound healing

A

GF for endothelium, smooth muscle, and fibroblasts

25
Q

Leukocyte adhesion deficiency genetics

A

AR defect of Integrins

26
Q

O2- to H2O2

A

Superoxide Dimutase

27
Q

O2 to O2-

A

Oxidative burst

NADPH oxidase

Source of CGD

28
Q

P-selectin released from

A

Weibel-Palade bodies bediated by histamine

29
Q

Scleroderma is

A

Autoimmune tissue damage with activation of fibroblasts and deposition of collagen

30
Q

Scleroderma lab findings

A

anti-DNA topoisomerase 1 (Scl-70)

31
Q

Sjögren lab findings

A

Anti-ribonucleoprotein AB (anti-SS-A/Ro and anti-SS-B/La)

32
Q

Sjögren sydrome is

A

Autoimmune destruction of lacrimal and salivary gland

33
Q

Sjögren syndrome increases risk of

A

B-cell (marginal zone) lymphoma

34
Q

SLE clinical

A
  1. Fever and weight loss
  2. Malar ‘butterfly’ rash
  3. Arthritis
  4. Pleuritis and pericarditis
  5. Psychosis
  6. Renal damage
  7. Libman-Sacks endocarditis
  8. Anemia, thrombocytopenia, leukopenia
35
Q

SLE lab findings

A

ANA (sensitive but not specific)

anti-dsDNA AB (Specific)

36
Q

TGF-α role in wound repair

A

Epithelial and fibroblast growth factor

37
Q

TGF-β role in wound repair

A

Fibroblast growth factor also inhibits inflammation

38
Q

TH1 secrete

A

IL-2 (T cell growth factor and CD8 T-cell activator)

IFN-γ (macrophag activator)

39
Q

TH2 secretes

A
  1. IL-4 (B-cell class switching to IgG and IgE)
  2. IL-5 (Eosinophil chemotaxis and activation, maturation of B cells, IgA class switching)
  3. IL-10 (Inhibits TH1)
40
Q

TLR activation results in

A

upregulation of NF-κB

41
Q

TLRs are activated by

A

Pathogen-associated molecular patterns (PAMPs)

42
Q

Toll-Like receptors (TLR) are

A

Mediators of acute inflammation

Located on cells of innate immune system

43
Q

Vit C in wound healing

A

Cofactor in hydroxylation of proline and lysine

44
Q

What AA metabolite attracts and activates PMN

45
Q

What AA metabolite mediates Pain and Fever

46
Q

What AA metabolites mediate vasodilation and increased vascular permeability

A
  1. PGI2
  2. PGD2
  3. PGE2
47
Q

What drugs cause SLE

A

Hydralazine

Procainamide

Isoniazid

48
Q

What test is used to screen CGD

A

Nitroblue tetrazolium test

(remains colorless if NADPH oxidase is defective)

49
Q

What type of HS is Sjögren sydnrome

50
Q

What type of HS is SLE

51
Q

What upregulates ICAM and VCAM

A

TNF and IL-1

52
Q

Wiskott-Aldrich sydrome clinical

A
  1. Thrombocytopenia
  2. Eczema
  3. Recurrent infections
53
Q

Wiskott-Aldrich syndrome due to

A

X-linked mutation of WASP

54
Q

X-linked Agammaglobulinemia is

A

Complete lack of Ig due to disordered B-cell maturation

55
Q

X-linked Agammaglobulinemia is due to

A

Mutated BtK

56
Q

Zinc in wound healing

A

Cofactor for collagenase which replaces Type 3 collagen with Type 1

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