Neoplasia Flashcards
Aflatoxin carcinogen associated with
Hepatocellular carcinoma
Alcohol carcinogen associated with
- Squamous cell Carcinoma of Oropharynx and upper esophagus
- Pancreatic carcinoma
- Hepatocellular CA
Alkylating agents carcinogen associated with
Leukemia/Lymphoma
Arsenic carcinogen associated with
- Squamous cell carcinoma of skin
- Lung Ca
- Angiosarcoma of liver
Burkitt translocation
t(8;14)
c-MYC
c-MYC translocation [t(8;14)] leads to
Burkitt lymphoma
Carcinomas spread via
Lymphatics
Chromogranin is marker for
Neuroendocrine cells
CML translocation
t(9;22)
TK-ABL
Cyclin D1 translocaiton [t(11;14)] leads to
Mantell cell lymphoma
Desmin marker for
Muscle
EBV carcinogen associated with
Nasopharyngeal Ca
Burkitt lymphoma
CNS lymphoma in AIDs
ER marker for
Breast epithelium
ERBB2[HER2/neu] amplification leads to
Subset of breast cancer
GFAP marker for
Neuroglia
HTLV-1 carcinogen associated with
Adult T-cell leukemia/lymphoma
Keratin is marker for
Epithelium
KIT point mutation leads to
Gastrointestinal stromal tumor
L-MYC amplification leads to
Small cell lung carcinoma
Mantle cell lymphoma translocation
t(11;14)
Cyclin D1
N-MYC amplification leads to
Neuroblastoma
Naphthylamine carcinogen associated with
Urethelial Carcinoma of bladder
Nitrosamines carcinogens associated with
Stomach Ca
Nitrosamines found in
Smoked foods
PDGFB overexpression leads to
Astrocytoma
RAS point mutation leads to
Carcinomas
Melanoma
Lymphoma
RET point mutation leads to
- MEN 2A
- MEN 2B
- Sporadic medullary carcinoma of thyroid
Carcinoma exceptions to hematogenous spread
RCC
Hepatocellular carcinoma
Follicular carcinoma
Choriocarcinoma
Sarcomas spread via
Hematogenous
Tyrosine kinase ABL translocation [t(9;22)] leads to
CML
Vimentin is marker for
Mesenchyme
Vinyl chloride carcinogen associated with
Angiosarcoma of liver
What is normal Kappa to Lambda light chain ratio
3:1
