Neoplasia Flashcards

1
Q

Aflatoxin carcinogen associated with

A

Hepatocellular carcinoma

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2
Q

Alcohol carcinogen associated with

A
  1. Squamous cell Carcinoma of Oropharynx and upper esophagus
  2. Pancreatic carcinoma
  3. Hepatocellular CA
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3
Q

Alkylating agents carcinogen associated with

A

Leukemia/Lymphoma

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4
Q

Arsenic carcinogen associated with

A
  1. Squamous cell carcinoma of skin
  2. Lung Ca
  3. Angiosarcoma of liver
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5
Q

Burkitt translocation

A

t(8;14)

c-MYC

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6
Q

c-MYC translocation [t(8;14)] leads to

A

Burkitt lymphoma

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7
Q

Carcinomas spread via

A

Lymphatics

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8
Q

Chromogranin is marker for

A

Neuroendocrine cells

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9
Q

CML translocation

A

t(9;22)

TK-ABL

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10
Q

Cyclin D1 translocaiton [t(11;14)] leads to

A

Mantell cell lymphoma

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11
Q

Desmin marker for

A

Muscle

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12
Q

EBV carcinogen associated with

A

Nasopharyngeal Ca

Burkitt lymphoma

CNS lymphoma in AIDs

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13
Q

ER marker for

A

Breast epithelium

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14
Q

ERBB2[HER2/neu] amplification leads to

A

Subset of breast cancer

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15
Q

GFAP marker for

A

Neuroglia

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16
Q

HTLV-1 carcinogen associated with

A

Adult T-cell leukemia/lymphoma

17
Q

Keratin is marker for

A

Epithelium

18
Q

KIT point mutation leads to

A

Gastrointestinal stromal tumor

19
Q

L-MYC amplification leads to

A

Small cell lung carcinoma

20
Q

Mantle cell lymphoma translocation

A

t(11;14)

Cyclin D1

21
Q

N-MYC amplification leads to

A

Neuroblastoma

22
Q

Naphthylamine carcinogen associated with

A

Urethelial Carcinoma of bladder

23
Q

Nitrosamines carcinogens associated with

A

Stomach Ca

24
Q

Nitrosamines found in

A

Smoked foods

25
Q

PDGFB overexpression leads to

A

Astrocytoma

26
Q

RAS point mutation leads to

A

Carcinomas

Melanoma

Lymphoma

27
Q

RET point mutation leads to

A
  1. MEN 2A
  2. MEN 2B
  3. Sporadic medullary carcinoma of thyroid
28
Q

Carcinoma exceptions to hematogenous spread

A

RCC

Hepatocellular carcinoma

Follicular carcinoma

Choriocarcinoma

29
Q

Sarcomas spread via

A

Hematogenous

30
Q

Tyrosine kinase ABL translocation [t(9;22)] leads to

A

CML

31
Q

Vimentin is marker for

A

Mesenchyme

32
Q

Vinyl chloride carcinogen associated with

A

Angiosarcoma of liver

33
Q

What is normal Kappa to Lambda light chain ratio

A

3:1