Sketchy Pharm: NNRTIs

Question 1

Name three NNRTIs.

Answer 1

Efavirenz, nevirapine, and delavirdine

Watch out: the third drug ends in the -dine suffix but is not an NRTI. Just remember Princess Delavir.

Question 2

How are NRTIs different from NNRTIs?

Answer 2

NNRTIs do not need to be phosphorylated.

Think of the knight running away with the P scroll in hand –he’s not needed by the elves.

Question 3

NNRTIs __________ inhibit reverse transcriptase.

Answer 3

allosterically (like the staff permanently jammed into the spell book)

Question 4

What side effects do the NNRTIs have?

Answer 4

Jaundice and liver failure (evidenced by the yellow stag with the big liver spot)
Teratogenic (giant tarantula)
SJS (mask being pulled off of goblin)

Question 5

Efavirenz specifically can cause ______________.

Answer 5

CNS changes such as hallucinations and nightmares

Think of the queen elf going crazy.

Question 6

Nevirapine is a potent CYP ___________.

Answer 6

inducer (like the shiny new license plate on the sleek carriage)