Sketchy Path: Idiopathic Pulmonary Fibrosis Flashcards
Idiopathic pulmonary fibrosis is characterized as a ___________ lung disease.
intrinsic restrictive (like the corset woman in the window)
Which demographic is most affected by idiopathic pulmonary fibrosis?
Males older than 60 (like the older butler with the tray and the “IDIOt” sign taped to his back by the pulmonary fibrosis tree)
Although the etiology is not fully understood, trace the broad outline of the pathogenesis of idiopathic pulmonary fibrosis.
IPF is thought to be caused by repeated inflammation that leads to damage of the type I pneumocytes (like the REPEATing red grapes –symbolizing alveolitis –and the cracked epithelial wall). Instead of normal healing, excess TGF-beta leads to fibrosis.
The most common pathologic pattern of idiopathic pulmonary fibrosis is ________________.
usual interstitial pneumonia (UIP): patches of fibrotic foci
(Think of the “jUIcy graPe” vines planted by the wall.)
The pleural surface of lungs with IPF look like ___________.
cobblestones (like the cobblestones beneath the tree)
How does IPF look on imaging?
As bilateral and diffuse reticular opacities in the lower lobes (like the bilateral, reticular pattern of the IPF tree)
The _____________ regions of the lung are often affected in IPF.
subpleural (like the little kid putting the fibrotic sticks beneath his pleural shirt)
Long-term IPF can lead to ___________ of the lungs.
honeycombing (dilation of airways and collapse of alveoli)
Think of the honeycomb on the table.
Describe COP.
COP is cryptogenic organizing pneumonia (formerly called bronchiolitis obliterans organizing pneumonia – BOOP). It is characterized by granulation tissue that obstructs the airways.
(Think of the little kid with the CaP gun shooting the cork going “BOOP!”)
What symptoms are suggestive of BOOP?
- Sudden onset cough and dyspnea
- Restrictive lung spirometry values
- Fever (head bandana with flames)
- Weight loss
It’s important to differentiate COP from pneumonia because ____________.
COP requires steroids for treatment (like the moons beneath the cap gun)
What are some causes of pulmonary fibrosis?
- Methotrexate
- Bleomycin
- Amiodarone
- Radiation (radiation shield wielded by girl)
(The drugs are represented by the mortar and pestle on the table.)
In addition to pulmonary fibrosis, those who have been treated with chest radiation can develop _____________.
pleural effusions (like the radiation girl’s dripping shirt from the fountain)
Those with radiation pneumonitis should be given ____________.
steroids (like the moons beneath the girl)
What systemic disorders can cause IPF?
- Lupus (like the wolf)
- Scleroderma (scleroderma scaly dragon)
- RA (like the lanterns)
