Sketchy Path: Idiopathic Pulmonary Fibrosis Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Idiopathic pulmonary fibrosis is characterized as a ___________ lung disease.

A

intrinsic restrictive (like the corset woman in the window)

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2
Q

Which demographic is most affected by idiopathic pulmonary fibrosis?

A

Males older than 60 (like the older butler with the tray and the “IDIOt” sign taped to his back by the pulmonary fibrosis tree)

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3
Q

Although the etiology is not fully understood, trace the broad outline of the pathogenesis of idiopathic pulmonary fibrosis.

A

IPF is thought to be caused by repeated inflammation that leads to damage of the type I pneumocytes (like the REPEATing red grapes –symbolizing alveolitis –and the cracked epithelial wall). Instead of normal healing, excess TGF-beta leads to fibrosis.

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4
Q

The most common pathologic pattern of idiopathic pulmonary fibrosis is ________________.

A

usual interstitial pneumonia (UIP): patches of fibrotic foci

(Think of the “jUIcy graPe” vines planted by the wall.)

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5
Q

The pleural surface of lungs with IPF look like ___________.

A

cobblestones (like the cobblestones beneath the tree)

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6
Q

How does IPF look on imaging?

A

As bilateral and diffuse reticular opacities in the lower lobes (like the bilateral, reticular pattern of the IPF tree)

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7
Q

The _____________ regions of the lung are often affected in IPF.

A

subpleural (like the little kid putting the fibrotic sticks beneath his pleural shirt)

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8
Q

Long-term IPF can lead to ___________ of the lungs.

A

honeycombing (dilation of airways and collapse of alveoli)

Think of the honeycomb on the table.

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9
Q

Describe COP.

A

COP is cryptogenic organizing pneumonia (formerly called bronchiolitis obliterans organizing pneumonia – BOOP). It is characterized by granulation tissue that obstructs the airways.

(Think of the little kid with the CaP gun shooting the cork going “BOOP!”)

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10
Q

What symptoms are suggestive of BOOP?

A
  • Sudden onset cough and dyspnea
  • Restrictive lung spirometry values
  • Fever (head bandana with flames)
  • Weight loss
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11
Q

It’s important to differentiate COP from pneumonia because ____________.

A

COP requires steroids for treatment (like the moons beneath the cap gun)

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12
Q

What are some causes of pulmonary fibrosis?

A
  • Methotrexate
  • Bleomycin
  • Amiodarone
  • Radiation (radiation shield wielded by girl)

(The drugs are represented by the mortar and pestle on the table.)

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13
Q

In addition to pulmonary fibrosis, those who have been treated with chest radiation can develop _____________.

A

pleural effusions (like the radiation girl’s dripping shirt from the fountain)

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14
Q

Those with radiation pneumonitis should be given ____________.

A

steroids (like the moons beneath the girl)

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15
Q

What systemic disorders can cause IPF?

A
  • Lupus (like the wolf)
  • Scleroderma (scleroderma scaly dragon)
  • RA (like the lanterns)
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