Pathoma: Benign [Breast] Tumors and Fibrocystic Changes Flashcards
Why does fibrosis happen in fibrocystic change?
The cystic dilations stretch the stromal tissue which causes fibrosis.
The classic physical exam finding in FCC is ____________.
a lumpy breast without a distinct mass
FCC is more common in ____________.
pre-menopausal women
Apocrine metaplasia sometimes appears in ______________.
FCC
Note: this is unique because metaplasia usually confers an increased risk of malignant transformation, but this is not the case with apocrine metaplasia of the breast.
FCC carries __________ the risk of malignancy.
no increase in
How can you diagnose ductal hyperplasia on histologic exam?
Increased layers of cells lining the ducts –that is, more than the usual bilayer
What is sclerosing adenosis?
SA is a proliferation of lobular cells that causes deposition of collagen and calcification within the TDLU.
SA portends a 2x increased risk of breast cancer.
Which has a higher risk of malignancy, sclerosing adenosis or atypical hyperplasia?
AH: 5x risk
SA and DH: 2x risk
The classic association with papillary lesions is ____________.
bloody discharge from the nipple
What cell type lines papillomas?
Two cells: the usual bilayer of epithelial cells and myoepithelium
Histologically, how can you tell if a papillary lesion is malignant?
The myoepithelial layer will be lost.
The most common breast tumor in premenopausal females is ________________, which is estrogen-sensitive.
fibroadenoma
Phyllodes tumors are similar to fibroadenomas, but they have an overgrowth of ______________.
the fibrous component (which accounts for their leaf-like projections)
Which benign lesion is more common in post-menopausal women?
Phyllodes tumors
