Sketchy Pharm: Interferon Alpha, Beta, Gamma Flashcards

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1
Q

Cytokines such as the interferons are released from ________________.

A

virally infected host cells (like the ill arcade manager handing out Cyto-Coins)

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2
Q

___________ upregulate interferon synthesis.

A

Interleukins

Think of the arcade clerk named Luke!

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3
Q

Interferon alpha is used to treat what infectious diseases?

A

HBV and HCV

Think of the Pac-Man machine with alphas for the A’s. The symbol is a hippo!

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4
Q

Other than hepatitis, interferon alpha is also used to treat what five diseases?

A
  • Hairy cell leukemia (hairy, ball-shaped villain)
  • Malignant melanoma (pigmented ghost villain)
  • Kaposi’s sarcoma (Kate’s Posies on the side and in the game)
  • Condyloma accuminata (ACCUMulated tokens in the jar)
  • Renal cell carcinoma (crab in the clear, kidney-shaped machine)
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5
Q

What are the side effects of interferon alpha?

A
  • Flu-like symptoms: malaise, fever, fatigue, cough (kid sweating, red, and tired on the machine)
  • Neurologic symptoms: retinopathy, tinnitus
  • Myelosuppression (the maze that Pac-Man is going through is bone-shaped and he’s eating RBCs!!)
  • Lupus (wolf stuffed animal falling out of machine)
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6
Q

Interferon beta is used to treat ______________.

A

multiple sclerosis (like the slogan on the Beta Invaders game: “Combat Lesions Through Time and Space!”)

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7
Q

How does interferon gamma work?

A

It activates macrophages and allows them to burst granulomas, which is why it is used in CGD.

(Think of the asteroids breaking open in Gammaga.)

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