Sketchy Pharm: Imatinib, Erlotinib, Sorafenib, Sunitinib, Vemurafenib Flashcards

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1
Q

How might you hear CML described?

A

As an overproduction of cells with mature granules (like the granules in the shipping crate that the bell came in)

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2
Q

Imatinib is used to treat what hematologic malignancy?

A

CML with the BCR:abl fusion protein (like the IMATation that Washington is doing in front of the tire swing tyrosine with the box of granules in front of his feet)

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3
Q

Imatinib is also used to treat ________________.

A

gastrointestinal stromal tumors (GIST), which stain positive for C-kit

(Think of the legislator with the protruding belly and the Congress KIT on it.)

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4
Q

Side effects of imatinib include ________________.

A

edema (like the edematous pantaloons worn by Washington)

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5
Q

What does erlotinib inhibit?

A

EGFR intermediates (like the EaRL Of TINIB: GeofFRey)

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6
Q

Erlotinib is used to treat _______________.

A

non-small cell lung cancer (like the LARGE cancer crab on the Earl’s chest)

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7
Q

What are side effects of erlotininb?

A
  • Acne (like the spots on the Earl’s face)

* Diarrhea (like the mud on his pants)

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8
Q

Which drugs inhibit VEGF?

A

Sunitinib (rising sun over vegetable patch) and sorafenib (soaring eagle over vegetable patch)

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9
Q

The classic cancer in which sorafenib and sunitinib is used is _____________.

A

RCC

This is because RCC overexpresses VEGF.

(Think of the bilateral crab suspender buckles worn by the farmer.)

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10
Q

Side effects of sorafinib and sunitinib include _____________.

A

hyperkeratosis and skin rash (like the sunburned farmer in the fields); hemorrhage (like the bleeding wound on the farmer)

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11
Q

Explain how the name vemurafenib helps you remember the genetic mutation that leads to melanoma.

A

More than half of all melanomas present with the V600E mutation in RAF: VEmuRAFenib.

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