Sketchy Micro: Picorniviridae Overview

Question 1

What kind of virus are the Picorniviruses?

Answer 1

• positive-sense RNA (orange sunset with + sign)

* naked (statue of David next to the PeaK aNimal zoo)

Question 2

How are the Picorniviruses transmitted?

Answer 2

Fecal-oral (like all the poop around the zoo)

Note: Rhinovirus is transmitted by respiratory droplets.

Question 3

How do Picorniviruses replicate?

Answer 3

They, like all positive-sense RNA viruses, replicate using host ribosomes in the cytoplasm.

(Think of the coin stamping machine near the zoo entrance.)

Question 4

Picorniviruses replicate by making ______________.

Answer 4

polyproteins that then get cleaved

Question 5

What are the three main groups of Picorniviruses?

Answer 5

•Hepatitis A (hippos with A band) 
•Enterovirus ("ENTER the aVIaRy")
   - Poliovirus (Pink flamingO)
   - Coxsackie A and B (Cockatoo) 
   - Echovirus (birds echoing) 
•Rhinovirus (rhinos in background)

Question 6

Enteroviruses are the number one cause of ______________.

Answer 6

aseptic meningitis

(The center aviary is shaped like a head and there’s a kid with a space helmet outside it, and the bags outside are labelled “No organisms” [because viral meningitis won’t culture], “No sugar,” [because viral meningitis won’t lower sugar], and “Protein” [because viral meningitis elevates CSF protein].)