Sketchy Pharm: Maraviroc, Fusion Inhibitors, Integrase Inhibitors

Question 1

The gag gene encodes for proteins that are where in the virion?

Answer 1

Within the capsid (just like the gagged prisoners in the center of the ship around the sundial)

Question 2

What proteins does gag encode?

Answer 2

It makes p24 and p7.

Think of the sundial having 24 hours 7 days a week.

Question 3

Which HIV protein allows for entry into host cells?

Answer 3

gp120 (like the 120 ram)

Question 4

What drug inhibits the entry of HIV virions?

Answer 4

Maraviroc (like the MARe rearing up in front of the poor defenseless squire)

Question 5

Enfuvirtide inhibits a protein created by which gene?

Answer 5

Env (specifically, it inhibits the gp41 fusion protein)

Question 6

Env genes have to be processed in ____________.

Answer 6

the endoplasmic reticulum

Think of the ER waves beneath the invading boat.

Question 7

The pol gene encodes for ________________.

Answer 7

new enzymes: reverse transcriptase, protease, and integrase

Think of Paul the blacksmith making new enzymes.

Question 8

Which protein does raltegravir inhibit?

Answer 8

It inhibits inTEGrase.

Think of the key deflector.

Question 9

Integrase inhibitors can cause _______________.

Answer 9

myopathy (represented by the CK bucket of chicken)