Skeletal homeostasis and Metabolic Bone Disease

Question 1

control of bone remodeling

Answer 1

osteocytes release Rank L which triggers osteoclast differentiation. OPG is released with high estrogen levels, which blocks Rank L binding and promotes osteoblasts.

Question 2

test resorption in the lab

Answer 2

serum: alkaline phosphate, P1NP, asteocalcin

Question 3

test remodeling in the lab

Answer 3

serum or urine: calcium, C.N telopetides (collagen cross links)

Question 4

what do cytes recreate to inhibit blasts

Answer 4

sclerostin

Question 5

pathologies

Answer 5

osteomalacia/rickets, osteoporosis, pagets

Question 6

Rickets!

Answer 6

poor mineralization due to D diffeciency (dietary, sunlight, malab, enzyme). leads to fractures, bone pain, hypocalcemia, bow legs.

Question 7

osteoporosis def

Answer 7

loss of bone mass>poor strength

Question 8

osteoporosis cause

Answer 8

excess respotion, no OPG decoy

Question 9

screen. osteoporosis

Answer 9

DXA (t score above 2.5), FRAX- predict 10 year (above 20 or 3 % is high

Question 10

treat

Answer 10

antiresorption drugs, anabolic drugs, vitamins and exercise

Question 11

examples of anabolic

Answer 11

monoclonal against sclerotin, pTH spikes

Question 12

pagets

Answer 12

chronic progressive focal abnormalities of bone development due to increase in absorption/reformation . Bone is weak/abnormal. Genetic and environmental causes

Question 13

pages diag

Answer 13

often asymptomatic, imaging prob enough!