scleroderma

Question 1

definition

Answer 1

fibrosis/hardening of the skin

Question 2

types

Answer 2

localized or generalized

Question 3

localized

Answer 3

morphed, linear (coup de sabre), no systemic involvement, not big deal

Question 4

generalized other names

Answer 4

cutaneous scleroderma, systemic sclerosis

Question 5

path

Answer 5

fibrous tissue, inflammation/ autoimmunity» vascular damage

Question 6

epi

Answer 6

RARE, but runs in rheum families, high ANA, D, chock tow Indians, twins, environ

Question 7

ABs

Answer 7

ANA 1:160 SEN, NPV, anticentromere SPEC, PPV, anti scl70 SPEC, PPV

Question 8

skin clinical

Answer 8

dermis fibrosis. collagen» reticular dermis, T cells infiltrate, surround blood vessels. peripheral» proximal

Question 9

CREST

Answer 9

old, non applicable nemonic. does NOT equal limited

Question 10

vascular clinical

Answer 10

ALL pts have raunauds

Question 11

raynauds

Answer 11

digital intimal proliferation- collagen hyperplasia, no arterial lumen, BAD

Question 12

pulm HTN

Answer 12

intimal fibrosis, late and limited

Question 13

lung clinical

Answer 13

interstitial, ground glass» honeycomb

Question 14

renal crisis triad

Answer 14

acute renal failure, abrupt HTN, micro angio apthic hemolytic anemia

Question 15

renal crisis treatment

Answer 15

ACE inhibitor- deal with high renin

Question 16

renal crisis path

Answer 16

collagen in vessels» narrowing, tricks body into thinking BP is LOW

Question 17

Nailed capillaroscopy

Answer 17

Distorted, dilated, contorted, drop out of capillaries

Question 18

What type of ace inhibitor used?

Answer 18

Short acting, like captor-is- don’t want hypotension

Renin stays high but effect avoided