Non opioids

Question 1

non opioid pain drug characteristics

Answer 1

no tolerance/dependence. ceiling to analgesia. most antipyretic

Question 2

which are not antipyretic

Answer 2

aspirin (only high dose) and acetaminophen (never)

Question 3

aspirin MOA

Answer 3

block cycloxygenase. Platelet inhibition is irreversible and requires low dose (vs high dose for antipyretic)

Question 4

Aspirin side effects

Answer 4

GI bleed, renal, hypersensitivity (asthma!!), tinnitus, Reyes.

Question 5

NSAIDS MOA

Answer 5

block cyclo

Question 6

MSAIDS effects

Answer 6

analgesic, antipyretic, anti inflam

Question 7

NSAIDS adverse

Answer 7

mainly same as aspirin, but pregnancy risk

Question 8

misoprostol

Answer 8

cytotec. prostaglandin E analog, protect stomach lining, but ABORTIVE- usually use prilosec

Question 9

cox 2 inhibitor example

Answer 9

celebrex

Question 10

cox 2 effects

Answer 10

analgesic, antipyretic, anti inflam

Question 11

cox 2 aderse

Answer 11

CARDIOVASC risk- alter T: P ratio (but less GI/platelet risk)

Question 12

acetaminophen

Answer 12

MOA unknown, analgesic and antipyretic but NOT anti inflam

Question 13

acetaminophen adverse

Answer 13

hepatotoxic- N acetyl Epstein neutralizes to save overdose - NAPQi

Question 14

corticosteroids MOA

Answer 14

transcription factor, decrease arachidonic acid formation (decrease leuk and prosta)

Question 15

steroid adverse chronic

Answer 15

decreased immune, adrenal, osteoporosis, fat redistribution

Question 16

steroid adverse acute

Answer 16

glucose intolerance/electrolyte imbalance (mineral overlap)

GI, CNS (mood), vaccines, avascular necrosis