intro to rheum and osteoarthritis

Question 1

what does rheumatology take care of?

Answer 1

non traumatic structural disorders, immune system disorders that focus on joints or on multi organs, chronic pain

Question 2

joint types (3)

Answer 2

synarthroidal, amphiarthroidal, diarthroidal

Question 3

synarthroidal

Answer 3

juncture of cranial plates

Question 4

amphiarthroidal

Answer 4

costosternal (slight movement)

Question 5

diarthroidal

Answer 5

movable joints. 2 bones, cartilage cover, muscle, lig, capsule, synovial tissue

Question 6

joint components

Answer 6

articular cartilage, joint capsule, synovium

Question 7

articular cartilage

Answer 7

chondrocytes, type II collagen, proteoglycans. Avasc and aneural

Question 8

joint capsule

Answer 8

Coll type I, thin type III, free nerves, mechanoreceptors

Question 9

synovium

Answer 9

lines the diarthredial joints (but NOT cartilage), thin matrix layer, capillaries, nerves, lymph, fluid and cells. NO BM»> free exchange

Question 10

synovial cells

Answer 10

A- MPhage like, B fibroblast like, synthetic

Question 11

synovial fluid

Answer 11

plasma transudate, HA, vicious, low cell count

Question 12

synovial transport

Answer 12

capilary (fenestrated)> interstitium>synovial fluid>cartilage

glucose has system, proteins filtered by size

Question 13

damaged joint characteristics

Answer 13

increased cells! <2k mechanical, >2k inflammation- infection/immune/crystals. altered transport- less glucose more protein

Question 14

mechanisms for joint damage

Answer 14

reactive 02- neutrophils, proteolytic enzymes, prostaglandins/leukotrines, increase synovial fluid volume, ischemia

Question 15

acute synovitis bacterial

Answer 15

RAPID cartilage loss

Question 16

crystal acute synovitis

Answer 16

severe pain but limited

Question 17

RA acute synovitis

Answer 17

sticky tissue damages cartilage and bone

Question 18

Lupus acute synovitis

Answer 18

inflammation but no destruction

Question 19

most common arthritis is

Answer 19

osteoarthritis

Question 20

damage in OA

Answer 20

ligament/cartilage leads to bone damage. Mostly in weight baring joints

Question 21

risk factors for OA

Answer 21

age, female, athletics, BMI, injury, heavy use

Question 22

clinical OA

Answer 22

stiffness, pain, mechanical, swelling, crepitus, deform, less mobility/joint space

Question 23

treat OA

Answer 23

orthotics, exercise, weight loss, pharm, surgery

Question 24

abnormal load, normal tissue OA

Answer 24

anatomical issue

Question 25

normal load, abnormal tisuse

Answer 25

injury, inflammation, metabolic