sero negative spond/ Lyme arthritis

Question 1

all sero negative share these features

Answer 1

RF negative, HLA b27, sacroiliac joint/spine, enthesitis, inflame at insertions, asymmetric. skin, eye, bowel, urethra

Question 2

types

Answer 2

ankylosing, IBD, psoriatic, reactive arthrtis (and lyme)

Question 3

ankylosing

Answer 3

men, 95% HLA, 3rd decade, stiffness decreases with activity, gradual spinal fusion, acute iritis, risk: genetic and environmental

Question 4

IBD

Answer 4

with or without related bowel activity. 70% HLA

Question 5

Psoriatic

Answer 5

closest resemblance to RA, asymmetric oligo, prominent enthiasis, sausage diget. 5% psoriatic pts

Question 6

reactive arthritis

Answer 6

antigen in joint but not septic, post urogenital/GI infection (gohnorhea or salmonella). oligoenthesis 1 wk post infection, most resolve, HLA 50%

Question 7

treat all besides lym

Answer 7

NSAIDS, anti TNF, biologics

Question 8

Lyme arthritis

Answer 8

stage 3 of untreated infection, 6+ or later, 50%, known cause for chronic . HLADRB1. treat: oral ABX

Question 9

lyme clinical

Answer 9

intermittent, recurring attacks. mild. 1 joint, usually knee.

Question 10

lyme path

Answer 10

active infection in synovium> T cells activate> RA like lesion. culture will be sterile but PCR shows infection

Question 11

rare chronic lyme arthritis

Answer 11

no infection… debris?

Hla haplotype?

Question 12

Which have enthesitis

Answer 12

Psoriatic, Ankylosis

Question 13

Hla b27 association

Answer 13

Reactive 50, Ibd 70, psoriatic weak, Ankylosis high