Anti Rheum Drugs Flashcards

1
Q

symptoms, NON first line drugs

A

NSAIDS, glucocorticoids

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2
Q

DMARD principles

A
Slow effect
Increase infection risk
No change to wound healing 
Regular follow up
Teratogenic
Increase risk of malignancy (maybe) (Lymphoma)
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3
Q

what DMARD is safe for pregnancy

A

Hydrocholroquine

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4
Q

first drug is

A

methotrexate

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5
Q

methotrexate info

A

MOA unknown, low dose, give with folic acid, NO ALCH

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6
Q

what can you give if pt drinks alch?

A

Leflumonide

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7
Q

Sulfasalazone side effect

A

bone marrow issue with G6PD deficiency

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8
Q

Mycophenolate/cyclopentolate

A

SLE life threatening disease- REALLY toxic. inhibitors DNA synthesis

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9
Q

biologic principles

A
Principles
All are DMARDS
Not oral
2nd/3rd line
Similar risks
Combo with non biologics
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10
Q

TNF agonist MOA

A

MAb, bind/block TNF receptor

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11
Q

TNF agonist side effects

A

reactive TB, infection, CHF, SLE/neurologic

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12
Q

abataceot/.tocilizumab

A

decrease T cell activation

Abat: block CTLA4

TOC: IL6 receptor

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13
Q

Rituzimab

A

Man to CD20- kill B/.pre B cells- not plasma

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14
Q

Rituzimab side effects

A

Leukoencephalopathy- reactivate JC virus

Infusion

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15
Q

RA treatment principles

A

Treat early with DMARD/ biologic

Screen Hep B/C/TB and vaccinate before treatment if possible

MTX first

3 monthdrug trial

Goal: decrease activity of disease/ remission

Vaccinate when appropriate (not live vaccines!!)

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16
Q

Biological side effects

A

Allergy, cost, injected, infections, Chf, neurological disease,

Large»> not cleared by kidney, renal function ok