Significant Apolipoproteins

Question 1

Plasma conc. = 100-200mg/dL
Main distribution= HDL

Answer 1

APO A-I

Question 2

Plasma conc. = 20-50mg/dL
Main distribution= HDL

Answer 2

APO A-II

Question 3

Plasma conc. = 10-20mg/dL
Main distribution= CM, VLDL, HDL

Answer 3

APO A-IV

Question 4

Plasma conc. = 70-125mg/dL
Main distribution= VLDL, IDL, LDL

Answer 4

APO B-100

Question 5

Plasma conc. = <5mg/dL
Main distribution= CM

Answer 5

APO B-48

Question 6

Plasma conc. = 5-8 mg/dL
Main distribution= CM, VLDL, HDL

Answer 6

APO C-I

Question 7

Plasma conc. = 3-7mg/dL
Main distribution= CM, VLDL, HDL

Answer 7

APO C-II

Question 8

Plasma conc. = 10-12mg/dL
Main distribution= CM, VLDL, HDL

Answer 8

APO C-III

Question 9

Plasma conc. = 3-15mg/dL
Main distribution= CM, VLDL, IDL, remnants and HDL

Answer 9

APO E

Question 10

function of APO A-I

Answer 10

structural, LCAT activator

Question 11

function of APO B-100

Answer 11

structural, LDL-R ligand

Question 12

function of APO B-48

Answer 12

structural, remnant receptor ligand

Question 13

function of APO C-II

Answer 13

structural, LPL cofactor

Question 14

function of APO C-III

Answer 14

structural, LPL inhibitor

Question 15

recognition factor that targets chylomicron and VLDL remnants to hepatic receptor

Answer 15

APO E

Question 16

• catalyzes the esterification of cholesterol
• free cholesterol + free FA = cholesterinesther

Answer 16

Lecithin Cholesterol Acyltransferase (LCAT)

Question 17

mediates endocytosis of lipoproteins especially LDL

Answer 17

LDL Receptor (LDL-R)

Question 18

catalyzes the hydrolysis of TG in lipoproteins releasing free fatty acids and glycerol to tissues

Answer 18

Lipoprotein Lipase (LPL)