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HAEMATOLOGY > [sicklecell] > Flashcards

[sicklecell] Flashcards

1
Q
A

Beta

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2
Q
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Glutamic acid –> valine

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3
Q
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HbS

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4
Q
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africans

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5
Q
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heterozygotes (HbAS)

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6
Q
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anaemia

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7
Q
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heterozygote (HbAS)

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8
Q
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hypoxia

anaethesia/enclosed spaces etc

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9
Q
A

vessels occluded by build up of sickle cells leading to painful ischaemia

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10
Q
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thalassaemia

HbC

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11
Q
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polymerisation of deformed HbS when deoxygenated

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12
Q
A

sickle cells are fragile

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13
Q
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sickle cells

Target cells

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14
Q
A

Hb electrophoresis

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15
Q
A

allows distinction between HbSS and HbAS

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16
Q
A

at birth (cord blood)

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17
Q
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pneumococcal prophylaxis

18
Q
A

sickle cell reduces spleen function i.e.immunocompromised

19
Q
A

vaso-occlusive crisis

20
Q
A

acute abdomen

21
Q
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vaso-occlusive crisis

22
Q
A

doppler US

23
Q
A

bone

e.g. avascular necrosis of femoral head

24
Q
A

priapism

25
Q
A

parvovirus b19

invades and destroys reticulocytes

26
Q
A

especially RBCs

27
Q
A

the spleen hasnt undergone atrophy

28
Q
A

intrasplenic trapping of RBCs usually affecting children

29
Q
A

sequestration crisis

death in 1-2 hours due to circulatory failure

30
Q
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infection

31
Q
A

hydroxycarbamide

32
Q
A

increases the level of HbF

33
Q
A

bone marrow transplant

34
Q
A

urgent transfusion

35
Q
A

acute chest syndrome

36
Q
A

pulmonary infiltrates

37
Q
A

tachypnoea
pain
fever

38
Q
A

O2
analgesia
emirical antibiotics
transfusion if severe (X-match)

39
Q
A

fat embolism

infection

40
Q
A

chlamydia

mycoplasma

41
Q
A

severe chest crisis
CNS event
multiorgan failure

HAEMATOLOGY (25 decks)

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