[haemolyticanaemia] Flashcards
unconjuated
normocytic
macrocytic
urinary urobilinogen
released during the breakdown of RBCs
large immature RBC production (reticulocytes)
T
intravascular
haem released in to serum binding with albumin. indicates increased serum haem
lowered
binds to free haem and removed by liver
haemosiderin in the urine
haptoglobin binding capacity is exceeded
autoimmune
antibodies on RBCs
pre-natal
before blood transfusion
Warm AIHA
Cold AIHA
paroxysmal cold haemoglobinuria
Drug induced
drugs bind to RBC cell membrane
primarily extra-vascular
the optimum temperature at which the antibodies bind to the RBCs
IgG
IgM
Cold
viruses
syphilis
Donath Landsteiner antibodies
TTP
HUS
DIC
haemolysis especially at night
thrombophila
X linked recessive
reduced glutathione production
an antioxidant
drugs
Broad beans/fava beans
ilness
bite cells
blister cells
denatured Hb components in RBCs
heinz body removed by the spleen.
henna
decreased ATP production
reduced RBC lifespan
spherocytosis
eliptocytosis
RBCs are less deformable
trapped in spleen
sickle cell
thalassaemia
oxidative crisis leading to denatured Hb
antibodies in serum against RBCS