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[ALL] Flashcards

1
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Child

commonest

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2
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Downs Syndrome

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3
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T

B

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4
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Antibody production

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5
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memory B cells

specific antibody production

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6
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CD4+

CD8+

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7
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Mature in Thymus

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8
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T helper

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9
Q
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CD4+ (T helper)

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10
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Cytokines

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11
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Cytotoxic T cells

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12
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1

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13
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all nucleated

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14
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x-rays

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15
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immature

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16
Q
A

bone marrow failure

17
Q
A

reduced WCC

18
Q
A

reduced platelet count

19
Q
A

infection
bleeding
anaemia

20
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tissue infiltration

21
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hepatosplenomegaly
lymphadenopathy
cranial nerve palsys
meningisms

22
Q
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tissue infiltration

23
Q
A

Pneumocystis jirovecii

24
Q
A

Blood film
CXR - lymphadenopathy
LP - CNS involvement

25
Q
A

Meningisms

CN palsy

26
Q
A

Tumour lysis syndrome

K+ and urate release

27
Q
A

Vincristine

Prednisolone

28
Q
A

arrests mitosis (inhibits microtubules assembly)

29
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A

Methotrexate

30
Q
A 
mercaptopurine (daily)
\+
Methotrexate (weekly)
\+
Vincristine + Prednisolone
31
Q
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immunosuppressive - competes for purine.

32
Q
A

matched related allogeneic marrow transplant

33
Q
A

after 1st remission

34
Q

[ALL]: What is the definition of ‘haematological remission’? (3)

A

no leukaemia in blood
normal/recovering blood count
<5% blasts in recovering marrow

35
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36
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HAEMATOLOGY (25 decks)

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