[b12/pernicious] Flashcards by Johannes Staufenberg

meat
fish
dairy

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4 years

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intrinsic factor

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thymidine

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pernicious anaemia
gastrectomy
low IF

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ileal resection
Crohns
coeliacs
bacterial overgrowth
tapeworm

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angular stomatitis

glossitis (beefy-red sore tongue)

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peripheral neuropathy

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B12 deficiency

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symmetrical dorsal and corticospinal tracts

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dorsal - joint position/vibration sense (ataxia)

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weakness

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extensor plantars
Lost reflexes at :
ankle
knee

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Spinothalamic (P+T)

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Atrophic gastritis (autoimmune)
Loss of IF
achlorhydria

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carcinoma of stomach

macrocytic

hypersegmented polymorphs

NO - production is stopped

it will be reduced or normal

pareital cell antibodies (found in 90%, also 10% without)

Intrinsic factor antibodies (specific but lower sens)

<40

Hydroxycobalamin 1mg IM

(alternate days for 2 weeks)

1mg IM every 3 months for life

alternate days every 2 week s

1mg IM hydroxycobalamin every 3 months

reticulocytosis after 5 days (therefore increased MCV)

SACDSC

oral b12