[myeloproliferative] Flashcards
1
Q
A
RBCs
Platelets
Fibroblasts
WBCs
2
Q
A
polycythaemia vera
3
Q
A
essential thrombocythaemia
4
Q
A
CML
5
Q
A
myelofibrosis
6
Q
A
relative (normal RBC mass, low plasma)
7
Q
A
polycythaemia rubra vera
8
Q
A
Hypoxia (e.g. altitude)
inappropriate EPO secretion
9
Q
A
JAK2
10
Q
A
platelets
WBCs
11
Q
A
hyperviscosity
12
Q
A
fingers
toes
(aka erythromyalgia)
13
Q
A
hot temperatures
“after hot bath”
14
Q
A
increased RBC turn over therefore release of yrate
15
Q
A
thrombus
16
Q
A
CML
17
Q
A
polycythaemia rubra vera
myelofibrosis
essential thrombocytopaenia
18
Q
A
raised
19
Q
A
hypercellularity
erythroid hyperplasia
20
Q
A
Radioactive chromium-51 - shows RBC mass
21
Q
A
normal O2 partial pressure
raised red cell mass on chromium-51 Ix
22
Q
A
low
23
Q
A
venesection
24
Q
A
hydroxycarbamide
25
[myeloproliferative]: polycythaemia rubra vera: what age is the cut off for Tx with hydoxycarbamide i.e. high risk
60
26
[myeloproliferative]: polycythaemia rubra vera: tx with hydroxycarbamide is indicated in older people and those who have had previous ...
thrombosis
27
[myeloproliferative]: polycythaemia rubra vera: what haemocrit are you aiming for
<0.45
28
[myeloproliferative]: polycythaemia rubra vera: if the patient is female of childbearing age 1st line tx is
alpha interferon
29
[myeloproliferative]: polycythaemia rubra vera: Alongside all treatments, regardless of age/risk/gender what dug is give
aspirin 75mg daily
30
[myeloproliferative]: polycythaemia rubra vera: how frequently should you monitor FBC
every 3 months
31
[myeloproliferative]: essential thrombocythaemia: > .... x10^9/L often
1000
32
[myeloproliferative]: essential thrombocythaemia: at increased risk of (2)
bleeding
| thrombosis
33
[myeloproliferative]: essential thrombocythaemia: why are you at increased risk of bleeding
abnormal platelet function
34
[myeloproliferative]: essential thrombocythaemia: Tx?
aspirin 75mg/day
+
Hydroxycarbamide (if >60 or previous thrombosis)
35
[myeloproliferative]: essential thrombocythaemia: when is hydrocarbamide given
>60
or
previous thrombosis
36
[myeloproliferative]: essential thrombocythaemia: microvascular occlusion can cause what symptoms (3)
headache
chest pain
light headedness
37
[myeloproliferative]: myelofibrosis: what causes the intense marrowfibrosis
release of PDGF (platelet derived growth factor)
38
[myeloproliferative]: myelofibrosis: what would you see on examination
massive splenomegaly
39
[myeloproliferative]: myelofibrosis: how might massive splenomegaly present as a symptom
abdominal discomfort
40
[myeloproliferative]: myelofibrosis: what is characteristic on film
teardrop RBCs
41
[myeloproliferative]: myelofibrosis: what symptoms might the Pt present with
abdominal discomfort
night sweats
wt loss
42
[myeloproliferative]: myelofibrosis: Tx is
marrow support
43
[myeloproliferative]: myelofibrosis: what 3 things does marrow support consist of
neutrophil support (regimens = sterile)
RBC transfusion
Platelets transfusion
