[bleeding] Flashcards
vasoconstriction
platelet plugging
coagulation cascade
haemostasis
coagulation
vasoconstriction
platelet plugging
Vascular
Platelet
coagulation
Henloch-Schonlein Purpura
small vessel vasculitis
aplastic anaemia
marrow suppression (e.g. cytotoxic drugs)
Marrow infiltration
megaloblastic anaemias
TTP
HUS
ITP
anti-platelet antibodies
infection
fluctuating of bleeding (menorrhagia/epistaxis)
prednisolone
if 1st line treatment fails
80
platelets destroyed by the antibodies
Aziathioprine
immunosuppression
IV Ig
Haemophilia
Von Willebrands
bring platelets and sub-endothelium into contact
platelets bind to eachother
bind to factor VIII (8) and prevent it from destruction
it activates factor 10
deficiency in vWF
mild symptoms
abnormal
variable symptoms
lack of vWF
low FVIII
(can be severe)
normal
normal
high
reduced synthesis of clotting factor
decreased absorption of vit K
10
9
7
2
IV vit K
FFP
factor VIII
factor IX
x linked recessive
high APTT
low Factor VIII
joints
muscles
nerve palsy
e.g. compartment syndrome
Desmopressin 0.3microg/kg/12hrs IVI over 20 mins
raises the levels of factor VIII
Recombinant factor VIII
cleaves fibrin
coagulation disorders causes delayed bleeding into joints/muscles
suddenly appearing Factor VIII antibodies
prolonged APTT
autoantibody to VIII
reduced factor VIII activity<50%
