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HAEMATOLOGY > [bleeding] > Flashcards

[bleeding] Flashcards

1
Q
A

vasoconstriction
platelet plugging
coagulation cascade

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2
Q
A

haemostasis

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3
Q
A

coagulation

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4
Q
A

vasoconstriction

platelet plugging

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5
Q
A

Vascular
Platelet
coagulation

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6
Q
A

Henloch-Schonlein Purpura

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7
Q
A

small vessel vasculitis

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8
Q
A

aplastic anaemia
marrow suppression (e.g. cytotoxic drugs)
Marrow infiltration
megaloblastic anaemias

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9
Q
A

TTP
HUS
ITP

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10
Q
A

anti-platelet antibodies

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11
Q
A

infection

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12
Q
A

fluctuating of bleeding (menorrhagia/epistaxis)

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13
Q
A

prednisolone

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14
Q
A

if 1st line treatment fails

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15
Q
A

80

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16
Q
A

platelets destroyed by the antibodies

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17
Q
A

Aziathioprine

immunosuppression

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18
Q
A

IV Ig

19
Q
A

Haemophilia

Von Willebrands

20
Q
A

bring platelets and sub-endothelium into contact
platelets bind to eachother
bind to factor VIII (8) and prevent it from destruction

21
Q
A

it activates factor 10

22
Q
A

deficiency in vWF

mild symptoms

23
Q
A

abnormal

variable symptoms

24
Q
A

lack of vWF
low FVIII

(can be severe)

25
Q
A

normal

26
Q
A

normal

27
Q
A

high

28
Q
A

reduced synthesis of clotting factor

decreased absorption of vit K

29
Q
A

10
9
7
2

30
Q
A

IV vit K

31
Q
A

FFP

32
Q
A

factor VIII

33
Q
A

factor IX

34
Q
A

x linked recessive

35
Q
A

high APTT

low Factor VIII

36
Q
A

joints

muscles

37
Q
A

nerve palsy

e.g. compartment syndrome

38
Q
A

Desmopressin 0.3microg/kg/12hrs IVI over 20 mins

39
Q
A

raises the levels of factor VIII

40
Q
A

Recombinant factor VIII

41
Q
A

cleaves fibrin

42
Q
A

coagulation disorders causes delayed bleeding into joints/muscles

43
Q
A

suddenly appearing Factor VIII antibodies

44
Q
A

prolonged APTT
autoantibody to VIII
reduced factor VIII activity<50%

HAEMATOLOGY (25 decks)

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