[CML] Flashcards
1
Q
A
myeloproliferative disorder
2
Q
A
4
3
Q
A
Philadelphia Ch. +
Philadelphia Ch. -
4
Q
A
CML
5
Q
A
Polycythaemia vera
Essential thrombocytosis
Myelofibrosis
6
Q
A
rarely
7
Q
A
Philadelphia Chr.
8
Q
A
t(9:22)
t=translocation
9
Q
A
BCR:Abl
10
Q
A
worse
11
Q
A
massive spenomegaly
hepatomegaly
bruising (platelet dysfunction)
12
Q
A
chronic/insidious
13
Q
A
weight loss
sweats
fever
tired
14
Q
A
Raised (>100x10^9/L)
15
Q
A
hypercellularity
16
Q
A
yes (all myeloid line)
17
Q
A
chronic
accelerated
blast transformation
18
Q
A
chronic
19
Q
A
blast transformation
20
Q
A
BCR:Abl gene tyrosine receptor
21
Q
A
imatinib
Nilotinib
22
Q
A
allogenic HLA matched stem cell transplant
23
Q
A
young patients (if risk low)
24
Q
A
Older patients
