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HAEMATOLOGY > [myeloma] > Flashcards

[myeloma] Flashcards

1
Q
A

serum

urine

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2
Q
A

monoclonal band

aka paraprotein

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3
Q
A

immunoglobulins

or fragments of

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4
Q
A

plasma cell

lympoplasmacytic cell

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5
Q
A

IgG

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6
Q
A

IgA

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7
Q
A

reduction in the levels of other immunoglobulins

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8
Q
A

immunoparesis

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9
Q
A

Bence-Jones proteins

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10
Q
A

free light immunoglobulin chains

kappa/lambda

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11
Q
A

yes

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12
Q
A

pancytopenia (anaemia/neutro/thrombocytopenia)
Recurrent bacterial infections
renal impairment
osteolytic bone lesions

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13
Q
A

increased activity

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14
Q
A

increased osteoclastic activity resulting in bone reduction

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15
Q
A

Back pain

fractures of long bones

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16
Q
A

marrow infiltration by plasma cells

17
Q
A

neutropenia

immunoparesis

18
Q
A

light chain deposition

19
Q
A

tamm-Horsfall protein (+bence jones)

20
Q
A

Rouleaux formation of RBCs

21
Q
A

pepper-pot lesions

22
Q
A

back ache

most frequent localisation

23
Q
A

plasma cell increased on biopsy
monoclonal band
evidence of end organ damage
bone lesions

24
Q
A

anaemia
renal function impaired
hypercalcaemia

25
Q
A

hyperviscosity
hypercalcaemia
AKI
spinal cord compression

26
Q
A

collapsing of vertebral bodies

27
Q
A

DexamethasoneIV 4mg/6hrs

28
Q
A

plasmapheresis

29
Q
A

removes light chains

30
Q
A 
IV saline (rehydrate)
Bisphosphonate
31
Q
A

transfusion

32
Q
A

Vincristine
Adriamycin
Dexamethasone

33
Q
A 
Melphalan
Prednisolone
\+-
bortezumab
\+-
Thalidomide
34
Q
A

renal failure

infection

35
Q
A

beta-2 microglobulin

HAEMATOLOGY (25 decks)

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