[bleedingIx] Flashcards
extrinsic
INR
0.9-1.2
I II V VII X
Warfarin
warfarin
INR/prothrombin
factor VII
increased consumption of multiple clotting factors
35-45 seconds
the intrinsic
heparin
binds to anti-thrombin III inhibitor
AT3 activates and inhibits thrombin
thrombin is responsible for fibrin deposition
warfarin inhibits synthesis of 1972 factors - K dependent.
7 is only in extrinsic pathway
converts fibrinogen to fibrin
10-15 seconds
fibrin degradation products
released from the x-linking during fibrinolysis
DIC
PE
DVT
two small cuts in forearm
<10 mins
PFA-100
platelet function analyzer 100
collagen + adrenaline
collagen + ADP
collagen + ADP are abnormal what does this indicate
platelet dysfunction is likely - further testing
aspirin ingestion
APTT
IM