sexually transmitted diseases

Question 1

neisseria is a

Answer 1

gram negative diplocci

Question 2

N. gonorrheae mucosal colonization starts by binding non-ciliated epithelium using adhesive ____ proteins, type IV pilli., acquires iron using _______ receptors and counters innate immune response by the ____ proteins that are anti-phagocytic and counters adaptive immune response by ________.

Answer 2

N. gonorrheae mucosal colonization starts by binding non-ciliated epithelium using adhesive Opa proteins, type IV pilli., acquires iorn using transferrin receptors and counters innate immune response by the Opa proteins that are anti-phagocytic and counters adaptive immune response by IgA1 protease.

Question 3

N. gonorrheae is able to spread to distant tissues by using the ____ proteins to penetrate the epithelium and it survives complement killing via surface modification with _______

Answer 3

N. gonorrheae is able to spread to distant tissues by using the OPA proteins to penetrate the epithelium and it survives complement killing via surface modification with sialic acid

Question 4

N. gonorrheae leads to damage such as (3)

Answer 4

1. LPS-mediated inflammation
2. PID
3. infertility and etopic pregnancy

Question 5

treatment for N. gonorrheae

Answer 5

azitrhomycin and doxycycline

Question 6

leading infectious cause of blindness

Answer 6

c. trachomatis “chlamydia”

Question 7

_______causes a common infection: mild URI, community-acquired pneumonia.

Answer 7

C. pneumoniae

Question 8

______causes a zoonotic disease: pneumonia, arthritis, and sepsis

parakeet

Answer 8

C. psittaci

Question 9

chlamydia encounters first the _________ which is the infectious form which is resistant to harsh treatment and entry is initiated in epithelial cells by ____________ to enter non-phagocytic cells . then they multiduplicate in the vacuole in the ______ body.

Answer 9

chlamydia encounters first the elementary body which is the infectious form which is resistant to harsh treatment and entry is initiated in epithelial cells by type III secretion system to enter non-phagocytic cells . then they multiduplicate in the vacuole in the reticulate body.

Question 10

to remain in the vacuole chlamydia interferes with the default_____________ to avoid delivery to the lysosome

Answer 10

to remain in the vacuole chlamydia interferes with the default membrane trafficking pathway to avoid delivery to the lysosome

Question 11

spread and damage of chlamydia

Answer 11

lysis of EB’s to infect other cells causing damage by cell-mediated

Question 12

Both Chlamydia and Gonorrhea cause arthritis however by different mechanism

Answer 12

Chlamydia- autoimmune

Gonorrhea- edema in joints

Question 13

what is the target of the antibiotic in chlamydia

Answer 13

the reticulate body which is metabolically active

Question 14

Ng is extracellular, causes chronic infection by

Answer 14

antigenic of pili;

phase variation of Opa proteins

Question 15

Ct is intracellular, causes chronic infection by

Answer 15

forming inclusions in host cells that contain:

Elementary bodies–infectious
Reticulate bodies–replicative

Question 16

treponema pallidum

Answer 16

spirochete… syphillis

Question 17

Syphilis infection can halt (ala’ Lyme disease)

Answer 17

yep , but ~50% progress

Question 18

entry of syphillis

Answer 18

local infection through a painless skin lesion where live spirochetes enter

Question 19

second stage of syphillis

Answer 19

early disseminated infection where the bug is raveling quickly, highly motile

Question 20

third stage syphillis

Answer 20

chronic infection, high antigenic variation

Question 21

damage seen in syphillis

Answer 21

inflammatory damage by increased lipoproteins production and we see neurological manifestations

Question 22

how do we test for syphillis?

Answer 22

just like lyme diseaseby two step serological test

1. rapid plasmin reagin
2. fluorescent treponemal ab

Question 23

what is the problem with reinfection?

Answer 23

there are no means to confirm reinfection because FTA test from prior infection remains positive

Question 24

treatment for syphillis

Answer 24

penicillin