Serotonin Neuropharm

Question 1

Only 20% of Serotonin comes from the __, the other 80% is found in the __ system

Answer 1

CNS; GI

Question 2

Serotonin affects 5 things in the CNS: ___ (depression/anxiety), ___, ___ (food cues), __ through inhibition/impulse and ____

Answer 2

mood, sleep, eating, behavior, pain

Question 3

Serotonin is made from ___, which is only found ____

Answer 3

tryptophan; exogenously

Question 4

The rate limiting enzyme of the conversion of tryptophan to 5-HT is

Answer 4

tryptoph hydroxylase

Question 5

Tph2 is the synthesis regulating gene for TpH in the

Answer 5

CNS

Question 6

Tryptophan > 5-HTT [>] 5-HT [what enzyme]

Answer 6

Aromatic amino acid decarboxylase

Question 7

The energy dependent ____ takes serotonin (and dopamine) from the cytoplasm into vesicles

Answer 7

VMAT

Question 8

Influx of __ allows the vesicle to bind to the nerve synapse wall and release

Answer 8

Ca2+

Question 9

5HT_ receptors in the medulla modulate the vomiting response

Answer 9

3

Question 10

5HT1 and 5HT2 receptors are ___ receptors

Answer 10

GPCRs

Question 11

Reuptake of 5-HT via the SERT transporter depends on the ___ ___

Answer 11

concentration gradient

Question 12

Autoreceptors of 5HT are on the __ synaptic neuron and ___ the biosynthetic pathway

Answer 12

pre; inhibit

Question 13

____ metabolizes serotonin both in the neuron and in the periphery through the liver

Answer 13

MAO-A

Question 14

Both MAO-A and Aldehyde dehydrogenase metabolize serotonin into __

Answer 14

5HIAA