Cocaine Flashcards

1
Q

What are the key determinants of an epidemic?

A

Low perceived risk and increasing supply

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2
Q

What is the mechanism of action of coke?

A

blocks dopamine reuptake at the synapse

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3
Q

Cocaine acts directly on the _____ ____

A

nucleus accumbens

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4
Q

3 major symptoms of cocaine use

A

Increased heart rate, paranoia, anxiety

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5
Q

What is the effect of coke and alcohol?

A

Reduces anxiety

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6
Q

What is the psychoactive by product of coke and alcohol?

A

cocaethylene

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7
Q

What is the positive effect of a heroin and coke speedball

A

Enhances effect of both drugs

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8
Q

CNS toxicity of coke include

A

seizures, stroke

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9
Q

Coke cardiac side effects include

A

MIs, chest pain

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10
Q

Other random side effects include (2)

A

Intestinal ischemia and perforated nasal septum

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11
Q

Effects of cocaine on pregnancy

A

low birthweight

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12
Q

Cocaine produces long term _____

A

sensitization

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13
Q

What is the manifestations of long term sensitization of cocaine?

A

Very strong craving

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14
Q

Chronic cocaine use shows increased grey matter in the ___ lobe

A

frontal

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15
Q

Less than ___ of cocaine dependent patients are clean after 6 months of treatment

A

half

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16
Q

What kind of cocaine counseling is the most effective?

A

Individual counseling, usually done by former addicts

17
Q

____ are very effective at getting people to quit coke

A

Vouchers

18
Q

What is the mechanism of action of Topiramate?

A

Increases GABA activity and decreases glutamate levels by blocking AMPA receptors

19
Q

Modafinil blocks the ____ transporter and may reduce the cocaine high

A

transporter

20
Q

Methamphetamine lasts ___ than cocaine by not only blocking reuptake but also increasing _____

A

longer; release into synapse