Cocaine Flashcards
What are the key determinants of an epidemic?
Low perceived risk and increasing supply
What is the mechanism of action of coke?
blocks dopamine reuptake at the synapse
Cocaine acts directly on the _____ ____
nucleus accumbens
3 major symptoms of cocaine use
Increased heart rate, paranoia, anxiety
What is the effect of coke and alcohol?
Reduces anxiety
What is the psychoactive by product of coke and alcohol?
cocaethylene
What is the positive effect of a heroin and coke speedball
Enhances effect of both drugs
CNS toxicity of coke include
seizures, stroke
Coke cardiac side effects include
MIs, chest pain
Other random side effects include (2)
Intestinal ischemia and perforated nasal septum
Effects of cocaine on pregnancy
low birthweight
Cocaine produces long term _____
sensitization
What is the manifestations of long term sensitization of cocaine?
Very strong craving
Chronic cocaine use shows increased grey matter in the ___ lobe
frontal
Less than ___ of cocaine dependent patients are clean after 6 months of treatment
half
What kind of cocaine counseling is the most effective?
Individual counseling, usually done by former addicts
____ are very effective at getting people to quit coke
Vouchers
What is the mechanism of action of Topiramate?
Increases GABA activity and decreases glutamate levels by blocking AMPA receptors
Modafinil blocks the ____ transporter and may reduce the cocaine high
transporter
Methamphetamine lasts ___ than cocaine by not only blocking reuptake but also increasing _____
longer; release into synapse
