Nicotine

Question 1

Nicotine is an _____ at ____ receptors

Answer 1

agonist; cholinergic

Question 2

The half life of nicotine is ___ hours, and metabolized in the __ by the ____ pathway

Answer 2

1.5 hours; liver; CYP2A6

Question 3

90% of nicotine is carried in the ____ of cigarretes

Answer 3

smoke

Question 4

Nicotine from smoke is absorbed into the bloodstream in ___ seconds

Answer 4

10-20

Question 5

A unique feature of nicotine receptors is that they ___ after use

Answer 5

desensitize

Question 6

The added genetic effects of smoking (heritability) is around __%

Answer 6

60

Question 7

Nicotinic receptors modulate the activity of _____ pre-synaptic vesicles

Answer 7

dopaminergic

Question 8

What is a cessation option that physicians can do in their office?

Answer 8

Brief intervention

Question 9

The 12 month abstinence rate for no intervention, brief, and intensive is what?

Answer 9

5, 10, 15 respectively

Question 10

Nicotine __ and __ quitting tools are available OTC

Answer 10

gum and patch

Question 11

The _ and _ mg gum is available OTC

Answer 11

2 and 4

Question 12

Nicotine nasal spray and inhaler are effective at relieving ___ ___ symptoms

Answer 12

nicotine withdrawal

Question 13

Transdermal Nicotine plus _____ can result in a more than 50% 12 month abstinence rate

Answer 13

bupropion

Question 14

Varenicline is a partial agonist at the Alpha 4 beta 2 ____ ____ receptor

Answer 14

nicotinic ach

Question 15

What are the agonist and antagonist effects of varenicline?

Answer 15

Agonist- relieves craving/withdrawal, antagonist- blocks reward effects of nicotine

Question 16

The most effective drug to quit smoking is ____; it’s major side effect is ____, but its most serious is ____

Answer 16

Varenicline; nausea; depression