Genetics of Mood

Question 1

Because of poly drug addicts, some risk of addiction is present without the regard to _______ class

Answer 1

pharmacologic

Question 2

A ____ variant in the ___ 5 region of the nicotinic ach receptor can lead to addiction due to decreased ____. The receptor is ___ active than a normal one

Answer 2

missense; alpha; aversion; less

Question 3

Acetaldehyde dehydrogenase homozygous for the ___ allele in asians is not as effective, leading to negative symptoms and low risk of alcoholism

Answer 3

lys

Question 4

The GABA-A risk allele increases the ___ of alcohol and gives homozygous drinkers more ___ quicker

Answer 4

euphoria; pleasure

Question 5

The ___1 balanced translocation is rare, and is more associated with ____

Answer 5

DISC; depression

Question 6

Although they are rare and with limited penetrance, there are several associated ___ __ ___ with SZ

Answer 6

copy number variants

Question 7

CACNa1C is a shared risk allele between __ and __, as well as the developmental disorder ____ (although these Timothy’s syndrome patients have a separate missense mutation)

Answer 7

bipolar disorder and schizophrenia; autism